Association of single nucleotide polymorphisms in the gene encoding GLUT1 and diabetic nephropathy in Brazilian patients with type 1 diabetes mellitus

Autor(es):Mostrar menos -

Marques, T. ^[1] ; Patente, T. A. ^[1] ; Monteiro, M. B. ^[1] ; Cavaleiro, A. M. ^[1] ; Queiroz, M. S. ^[2] ; Nery, M. ^[2] ; de Azevedo, M. J. ^[3] ; Canani, L. H. ^[3] ; Parisi, M. C. ^[4] ; Moura-Neto, A. ^[4] ; Passarelli, M. ^[5] ; Giannella-Neto, D. ^[6] ; Machado, U. F. ^[7] ; Correa-Giannella, M. L. ^{[8, 1]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Lab Endocrinol Celular & Mol LIM 25, BR-01246903 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin, Div Endocrinol, BR-05403000 Sao Paulo, SP - Brazil

^[3] Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Div Endocrinol, BR-90035903 Porto Alegre, RS - Brazil

^[4] Univ Estadual Campinas UNICAMP, Fac Med, Dept Clin Med, Div Endocrinol, BR-13084971 Campinas, SP - Brazil

^[5] Univ Sao Paulo, Fac Med, Lab Lipides LIM 10, BR-01246903 Sao Paulo, SP - Brazil

^[6] Univ Nove Julho UNINOVE, Programa Posgrad Med, Sao Paulo, SP - Brazil

^[7] Univ Sao Paulo, Inst Ciencias Biomed, Dept Fisiol & Biofis, BR-05508900 Sao Paulo, SP - Brazil

^[8] FMUSP, Ctr Terapia Celular & Mol NUCEL NETCEM, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Clinica Chimica Acta; v. 444, p. 170-175, APR 15 2015.
• Citações Web of Science: 6

Resumo

Mesangial cells subject to high extracellular glucose concentrations, as occur in hyperglycaemic states, are unable to down regulate glucose influx, resulting in intracellular activation of deleterious biochemical pathways. A high expression of GLUT1 participates in the development of diabetic glomerulopathy. Variants in the gene encoding GLUT1 (SLC2A1) have been associated to this diabetic complication. The aim of this study was to test whether polymorphisms in SLC2A1 confer susceptibility to diabetic nephropathy (DN) in Brazilian type I diabetes patients. Four polymorphisms (rs3820589, rs1385129, rs841847 and rs841848) were genotyped in a Brazilian cohort comprised of 452 patients. A prospective analysis was performed in 155 patients. Mean duration of follow-up was 5.6 +/- 2.4 years and the incidence of renal events was 18.0%. The rs3820589 presented an inverse association with the prevalence of incipient DN (OR: 0.36,95% CI: 0.16 - 0.80, p = 0.01) and with progression to renal events (HR: 0.20; 95% CI: 0.03 - 0.70; p = 0.009). AGGT and AGAC haplotypes were associated with the prevalence of incipient ON and the AGAC haplotype was also associated with the prevalence of established/advanced DN. In conclusion, rs3820589 in the SLC2A1 gene modulates the risk to DN in Brazilian patients with inadequate type I diabetes control. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/04831-1 - Novos moduladores do controle glicêmico e do desenvolvimento de complicações crônicas no Diabetes mellitus: perspectivas preventivas e terapêuticas
• Beneficiário: Ubiratan Fabres Machado
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 09/09276-3 - Estudo de Polimorfismos em Genes que Codificam Enzimas Antioxidantes e Transportadores de Glicose e sua Associação com a Susceptibilidade a Complicações Crônicas em Pacientes Diabéticos Tipo 1
• Beneficiário: Maria Lucia Cardillo Corrêa Giannella
• Modalidade de apoio: Auxílio à Pesquisa - Regular