Leukocyte telomere length in patients with schizophrenia: A meta-analysis

Autor(es)

Polho, G. B. ^[1] ; De-Paula, V. J. ^[1] ; Cardillo, G. ^[1] ; dos Santos, B. ^[2] ; Kerr, D. S. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci LIM 27, BR-05403010 Sao Paulo, SP - Brazil

^[2] Univ Sao Paulo, Sch Nursing, Res Assistance Serv, BR-05403010 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-05403010 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: SCHIZOPHRENIA RESEARCH; v. 165, n. 2-3, p. 195-200, JUL 2015.
• Citações Web of Science: 35

Resumo

Schizophrenia has been suggested as a syndrome of accelerated aging. Telomere length (TL) decrease is considered one biological marker associated with age and can be accelerated by pathological characteristics present in schizophrenia. Several studies evaluated TL in schizophrenia, but the results are still controversial. The aim of this study was to conduct a meta-analysis of the existing results of TL in leukocytes of individuals with schizophrenia compared to healthy controls. A search was performed in PubMed, using the keywords `telomere schizophrenia' and `telomere psychosis'. We included data from original articles that measured TL in leukocytes of human patientswith schizophrenia and healthy control subjects. 45 articles were found, but only 7 met our criteria. Telomere length of controls was not statistically different from that of patients with schizophrenia (p = 0.07). Crossvalidation with the leave-one-out method resulted in a significant model (p = 0.03) in which TL of individuals with schizophrenia is smaller than control (SMD = 0.38; 95% CI = {[}0.05, 0.72]). We also propose a biological pathway through which schizophrenia could promote telomere erosion and how antipsychotics might compensate this loss. There are few studies made on this subject with diverse methodology and heterogeneous sample. Some articles did not consider other possible influences on TL. Overall our results suggest that TL is decreased in schizophrenia. Although this is consistent with the idea of accelerated aging, schizophrenia is a complex disease and there are several factors that influence TL that should be controlled in future studies. (C) 2015 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/01352-8 - Efeito do lítio na regulação da expressão gênica por micro RNAs em modelo da Doença de Alzheimer por toxicidade de beta-amilóide em cultura primária de neurônios
• Beneficiário: Daniel Shikanai Kerr
• Modalidade de apoio: Auxílio à Pesquisa - Regular