Reassortment and distinct evolutionary dynamics of Rift Valley Fever virus genomic segments

Autor(es)

Freire, Caio C. M. ^[1] ; Iamarino, Atila ^[1] ; Ly Soumare, Peinda O. ^[2] ; Faye, Ousmane ^[2] ; Sall, Amadou A. ^[2] ; Zanotto, Paolo M. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil

^[2] Inst Pasteur, Dakar - Senegal

• Tipo de documento: Artigo Científico
• Fonte: SCIENTIFIC REPORTS; v. 5, JUN 23 2015.
• Citações Web of Science: 9

Resumo

Rift Valley Fever virus (RVFV) is a member of Bunyaviridae family that causes a febrile disease affecting mainly ruminants and occasionally humans in Africa, with symptoms that range from mid to severe. RVFV has a tri-segmented ssRNA genome that permits reassortment and could generate more virulent strains. In this study, we reveal the importance of reassortment for RVFV evolution using viral gene genealogy inference and phylodynamics. We uncovered seven events of reassortment that originated RVFV lineages with discordant origins among segments. Moreover, we also found that despite similar selection regimens, the three segments have distinct evolutionary dynamics; the longer segment L evolves at a significant lower rate. Episodes of discordance between population size estimates per segment also coincided with reassortment dating. Our results show that RVFV segments are decoupled enough to have distinct demographic histories and to evolve under different molecular rates. (AU)

• Processo FAPESP: 10/19341-4 - Caracterização biológica de recombinantes naturais e artificiais entre os subtipos B e F de HIV-1
• Beneficiário: Paolo Marinho de Andrade Zanotto
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/04818-5 - Evolução e filodinâmica dos recombinantes BF de HIV-1 da América do Sul
• Beneficiário: Atila Iamarino
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/15144-8 - Evolução genômica de grandes vírus de DNA de insetos
• Beneficiário: Atila Iamarino
• Modalidade de apoio: Bolsas no Exterior - Estágio de Pesquisa - Pós-Doutorado
• Processo FAPESP: 14/06090-4 - Estimativa da diversidade intra e inter populacional gênica e genética do baculovírus Anticarsia gemmatalis múltiplo nucleopoliedrovírus (AgMNPV) em isolados de campo na América do Sul
• Beneficiário: Caio César de Melo Freire
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado