| Full text | |
| Author(s): |
Freire, Caio C. M.
[1]
;
Iamarino, Atila
[1]
;
Ly Soumare, Peinda O.
[2]
;
Faye, Ousmane
[2]
;
Sall, Amadou A.
[2]
;
Zanotto, Paolo M. A.
[1]
Total Authors: 6
|
| Affiliation: | [1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Inst Pasteur, Dakar - Senegal
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | SCIENTIFIC REPORTS; v. 5, JUN 23 2015. |
| Web of Science Citations: | 9 |
| Abstract | |
Rift Valley Fever virus (RVFV) is a member of Bunyaviridae family that causes a febrile disease affecting mainly ruminants and occasionally humans in Africa, with symptoms that range from mid to severe. RVFV has a tri-segmented ssRNA genome that permits reassortment and could generate more virulent strains. In this study, we reveal the importance of reassortment for RVFV evolution using viral gene genealogy inference and phylodynamics. We uncovered seven events of reassortment that originated RVFV lineages with discordant origins among segments. Moreover, we also found that despite similar selection regimens, the three segments have distinct evolutionary dynamics; the longer segment L evolves at a significant lower rate. Episodes of discordance between population size estimates per segment also coincided with reassortment dating. Our results show that RVFV segments are decoupled enough to have distinct demographic histories and to evolve under different molecular rates. (AU) | |
| FAPESP's process: | 10/19341-4 - Biological characterization of natural and artificial HIV-1 recombinants between subtypes B and F |
| Grantee: | Paolo Marinho de Andrade Zanotto |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/04818-5 - Evolution and phyloynamics of HIV-1 BF recombinants from South America |
| Grantee: | Atila Iamarino |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |
| FAPESP's process: | 13/15144-8 - Genomic evolution of large DNA viruses of insects |
| Grantee: | Atila Iamarino |
| Support Opportunities: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 14/06090-4 - Estimative of the intra and inter genic and genetic diversity from the populations of the baculovirus Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) in field isolates from South America |
| Grantee: | Caio César de Melo Freire |
| Support Opportunities: | Scholarships in Brazil - Post-Doctoral |