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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Reassortment and distinct evolutionary dynamics of Rift Valley Fever virus genomic segments

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Author(s):
Freire, Caio C. M. [1] ; Iamarino, Atila [1] ; Ly Soumare, Peinda O. [2] ; Faye, Ousmane [2] ; Sall, Amadou A. [2] ; Zanotto, Paolo M. A. [1]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Microbiol, Lab Mol Evolut & Bioinformat, Sao Paulo - Brazil
[2] Inst Pasteur, Dakar - Senegal
Total Affiliations: 2
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 5, JUN 23 2015.
Web of Science Citations: 9
Abstract

Rift Valley Fever virus (RVFV) is a member of Bunyaviridae family that causes a febrile disease affecting mainly ruminants and occasionally humans in Africa, with symptoms that range from mid to severe. RVFV has a tri-segmented ssRNA genome that permits reassortment and could generate more virulent strains. In this study, we reveal the importance of reassortment for RVFV evolution using viral gene genealogy inference and phylodynamics. We uncovered seven events of reassortment that originated RVFV lineages with discordant origins among segments. Moreover, we also found that despite similar selection regimens, the three segments have distinct evolutionary dynamics; the longer segment L evolves at a significant lower rate. Episodes of discordance between population size estimates per segment also coincided with reassortment dating. Our results show that RVFV segments are decoupled enough to have distinct demographic histories and to evolve under different molecular rates. (AU)

FAPESP's process: 10/19341-4 - Biological characterization of natural and artificial HIV-1 recombinants between subtypes B and F
Grantee:Paolo Marinho de Andrade Zanotto
Support Opportunities: Regular Research Grants
FAPESP's process: 12/04818-5 - Evolution and phyloynamics of HIV-1 BF recombinants from South America
Grantee:Atila Iamarino
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 13/15144-8 - Genomic evolution of large DNA viruses of insects
Grantee:Atila Iamarino
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 14/06090-4 - Estimative of the intra and inter genic and genetic diversity from the populations of the baculovirus Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) in field isolates from South America
Grantee:Caio César de Melo Freire
Support Opportunities: Scholarships in Brazil - Post-Doctoral