Research Grants 15/12944-9 - Rotavirus, Genótipo - BV FAPESP
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Investigating the evoltution of animal rotavirus strains infecting humans

Abstract

Group A rotaviruses (RVA) are the main cause of acute viral gastroenteritis in both humans and animal. Global surveillance of circulating RVA in the human population has revealed the presence of several uncommon genotypes, including Brazil. Many of these have been found in domestic animals, and phylogenetic analysis suggests that they arose in the human population through zoonotic transmission. The distribution and evolution of human RVA strains is important for vaccine development and effectiveness. In 2006 an attenuated monovalent vaccine was included in the Brazilian National Immunization Program, preventing severe RVA gastroenteritis, and inducing significant reduction in the frequency of RVA detection in children with gastroenteritis. In setting where RVA vaccine coverage is high, such as in Brazil, vaccine pressure could select for replacement of common strains (similar to those included in RVA vaccines) with uncommon strains, some of which could be generated by reassortment between human and animal RVA. The Enteric Diseases Laboratory (NDE) of Adolfo Lutz Institute is a macro-regional reference center for RVA surveillance, Ministry of Health (MS)-Brazil. Convenient stool samples from patients with acute gastroenteritis were sent to the NDE for viral diagnosis. The fecal specimens are investigated for RVA by commercial ELISA kit and genotyped by RT-PCR for the two outer capsid proteins: VP4 (P genotype) and VP7 (G genotype). The detection of unusual/rare G and P genotypes association strongly suggest interspecies transmission. Since 2008, the RVA classification system based on molecular characterization of the 11 genes (genomic constellation) have been used to study viral evolution, and provided an excellent means of deciphering the true origin of unconventional strains, especially those derived from interspecies transmission and subsequent adaptation to human host. Tracking virus evolution and gaining an understanding of the role that animal RVA strains play is important for continued development of vaccine strategies and genotyping surveillance. The aim of this study is investigate the dynamic between human and animal RVA strains using complete genome sequencing of RVA strains displaying rare/unusual G (VP7) and P (VP4) genotypes combinations, following phylogetic analysis. (AU)

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Scientific publications (22)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ARANHA WATANABE, ARIPUANA SAKURADA; LUCHS, ADRIANA; LEAL, ELCIO; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; et al. Complete Genome Sequences of Six Human Bocavirus Strains from Patients with Acute Gastroenteritis in the North Region of Brazil. MICROBIOLOGY RESOURCE ANNOUNCEMENTS, v. 6, n. 17, . (15/12944-9, 16/01735-2, 17/00021-9)
LUCHS, ADRIANA; DA COSTA, ANTONIO CHARLYS; CILLI, AUDREY; VASCONCELOS KOMNINAKIS, SHIRLEY CAVALCANTE; COMPAGNOLI CARMONA, RITA DE CASSIA; BOEN, LAIS; MORILLO, SIMONE GUADAGNUCCI; SABINO, ESTER CERDEIRA; SAMPAIO TAVARES TIMENETSKY, MARIA DO CARMO. Spread of the emerging equine-like G3P[8] DS-1-like genetic backbone rotavirus strain in Brazil and identification of potential genetic variants. JOURNAL OF GENERAL VIROLOGY, v. 100, n. 1, p. 7-25, . (15/12944-9, 17/00021-9, 16/01735-2)
LEAL, ELCIO; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; et al. Recombinant Strains of Human Parechovirus in Rural Areas in the North of Brazil. Viruses-Basel, v. 11, n. 6, . (15/12944-9, 17/00021-9, 16/01735-2)
LUCHS, ADRIANA; LEAL, ELCIO; KOMNINAKIS, SHIRLEY VASCONCELOS; DE PADUA MILAGRES, FLAVIO AUGUSTO; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; GILL, DANIELLE ELISE; DENG, XUTAO; DELWART, ERIC; SABINO, ESTER CERDEIRA; et al. Wuhan large pig roundworm virus identified in human feces in Brazil. VIRUS GENES, v. 54, n. 3, p. 470-473, . (15/12944-9, 17/00021-9, 16/01735-2)
ROSA, ULISSES ALVES; RIBEIRO, GEOVANI DE OLIVEIRA; VILLANOVA, FABIOLA; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; TAHMASEBI, ROOZBEH; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; et al. First identification of mammalian orthoreovirus type 3 by gut virome analysis in diarrheic child in Brazil. SCIENTIFIC REPORTS, v. 9, . (15/12944-9, 17/00021-9, 16/01735-2)
MEDEIROS, ROBERTA SALZONE; FRANCA, YASMIN; VIANA, ELLEN; DE AZEVEDO, LAIS SAMPAIO; GUIDUCCI, RAQUEL; DE LIMA NETO, DANIEL FERREIRA; DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA. Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone. Viruses-Basel, v. 15, n. 3, p. 34-pg., . (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)
RAMOS, ENDRYA DO SOCORRO FORO; RIBEIRO, GEOVANI DE OLIVEIRA; VILLANOVA, FABIOLA; MILAGRES, FLAVIO AUGUSTO DE PADUA; BRUSTULIN, RAFAEL; ARAUJO, EMERSON LUIZ LIMA; PANDEY, RAMENDRA PATI; RAJ, V. SAMUEL; DENG, XUTAO; DELWART, ERIC; et al. Composition of Eukaryotic Viruses and Bacteriophages in Individuals with Acute Gastroenteritis. Viruses-Basel, v. 13, n. 12, . (20/14786-0, 15/12944-9, 17/00021-9)
TINKER, RORY J.; DA COSTA, ANTONIO CHARLYS; TAHMASEBI, ROOZBEH; MILAGRES, FLAVIO AUGUSTO DE PADUA; DOS SANTOS MORAIS, VANESSA; PANDEY, RAMENDRA PATI; JOSE-ABREGO, ALEXIS; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; CUNHA, MARIANA SEQUETIN; et al. Norovirus strains in patients with acute gastroenteritis in rural and low-income urban areas in northern Brazil. ARCHIVES OF VIROLOGY, v. 166, n. 3, p. 905-913, . (17/00021-9, 15/12944-9, 16/01735-2, 19/21706-5)
LUCHS, ADRIANA; LEAL, ELCIO; TARDY, KAELAN; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; et al. The rare enterovirus c99 and echovirus 29 strains in Brazil: potential risks associated to silent circulation. Memórias do Instituto Oswaldo Cruz, v. 114, . (17/00021-9, 15/12944-9, 16/01735-2)
AUDREY CILLI; ADRIANA LUCHS; ELCIO LEAL; DANIELLE GILL; FLAVIO AUGUSTO DE PÁDUA MILAGRES; SHIRLEY VASCONCELOS KOMNINAKIS; RAFAEL BRUSTULIN; MARIA DA APARECIDA RODRIGUES TELES; MÁRCIA CRISTINA ALVES BRITO SAYÃO LOBATO; ROGÉRIO TOGISAKI DAS CHAGAS; et al. Human sapovirus GI.2 and GI.3 from children with acute gastroenteritis in northern Brazil. Memórias do Instituto Oswaldo Cruz, v. 114, . (16/01735-2, 15/12944-9, 17/00021-9)
DA COSTA, ANTONIO CHARLYS; LEAL, ELCIO; GILL, DANIELLE; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; BRUSTULIN, RAFAEL; RODRIGUES TELES, MARIA DA APARECIDA; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; et al. Discovery of Cucumis melo endornavirus by deep sequencing of human stool samples in Brazil. VIRUS GENES, v. 55, n. 3, p. 332-338, . (15/12944-9, 17/00021-9, 16/01735-2)
DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; et al. Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil. SCIENTIFIC REPORTS, v. 8, . (15/12944-9, 17/00021-9, 16/01735-2)
FORO RAMOS, ENDRYA DO SOCORRO; ROSA, ULISSES ALVES; RIBEIRO, GEOVANI DE OLIVEIRA; VILLANOVA, FABIOLA; DE PADUA MILAGRES, FLAVIO AUGUSTO; BRUSTULIN, RAFAEL; MORAIS, VANESSA DOS SANTOS; BERTANHE, MAYARA; MARCATTI, ROBERTA; ARAUJO, EMERSON LUIZ LIMA; et al. High Heterogeneity of Echoviruses in Brazilian Children with Acute Gastroenteritis. Viruses-Basel, v. 13, n. 4, . (19/21706-5, 17/00021-9, 15/12944-9)
FORO RAMOS, ENDRYA DO SOCORRO; ROSA, ULISSES ALVES; RIBEIRO, GEOVANI DE OLIVEIRA; VILLANOVA, FABIOLA; DE PADUA MILAGRES, FLAVIO AUGUSTO; BRUSTULIN, RAFAEL; MORAIS, VANESSA DOS SANTOS; LIMA ARAUJO, EMERSON LUIZ; PANDEY, RAMENDRA PATI; RAJ, V. SAMUEL; et al. Multiple clades of Husavirus in South America revealed by next generation sequencing. PLoS One, v. 16, n. 3, . (17/00021-9, 15/12944-9)
DE AZEVEDO, LAIS SAMPAIO; FRANCA, YASMIN; VIANA, ELLEN; MEDEIROS, ROBERTA SALZONE; MORILLO, SIMONE GUADAGNUCCI; GUIDUCCI, RAQUEL; RIBEIRO, CIBELE DANIEL; VIEIRA, HELOISA ROSA; BARRIO-NUEVO, KAROLINA MORALES; CUNHA, MARIANA SEQUETIN; et al. Lack of molecular evidence of fecal-borne viruses in capybaras from Sao Paulo state, Brazil, 2018-2020: a minor public health issue. Brazilian Journal of Microbiology, v. N/A, p. 9-pg., . (20/14786-0, 20/02469-0, 15/12944-9, 20/11182-6, 19/21706-5)
DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; et al. Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus. Viruses-Basel, v. 10, n. 10, . (15/12944-9, 16/01735-2, 17/00021-9)
MARCELLE SILVA-SALES; ELCIO LEAL; FLAVIO AUGUSTO DE PÁDUA MILAGRES; RAFAEL BRUSTULIN; VANESSA DOS SANTOS MORAIS; ROBERTA MARCATTI; EMERSON LUIZ LIMA ARAÚJO; STEVEN S. WITKIN; XUTAO DENG; ESTER CERDEIRA SABINO; et al. Genomic constellation of human Rotavirus A strains identified in Northern Brazil: a 6-year follow-up (2010-2016). Revista do Instituto de Medicina Tropical de São Paulo, v. 62, . (15/12944-9, 17/00021-9, 19/21706-5)
RIBEIRO, GEOVANI DE OLIVEIRA; LUCHS, ADRIANA; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; DE DEUS ALVES SOARES, CASSIA VITORIA; et al. Detection and Characterization of Enterovirus B73 from a Child in Brazil. Viruses-Basel, v. 11, n. 1, . (15/12944-9, 17/00021-9, 16/01735-2)
LUCHS, ADRIANA; TARDY, KAELAN; TAHMASEBI, ROOZBEH; MORILLO, SIMONE GUADAGNUCCI; MILAGRES, FLAVIO AUGUSTO DE PADUA; MORAIS, VANESSA DOS SANTOS; BRUSTULIN, RAFAEL; TELES, MARIA DA APARECIDA RODRIGUES; DE AZEVEDO, LAIS SAMPAIO; DE SOUZA, ELLEN VIANA; et al. Human astrovirus types 1, 4 and 5 circulating among children with acute gastroenteritis in a rural Brazilian state, 2010-2016. ARCHIVES OF VIROLOGY, v. 166, n. 11, . (19/21706-5, 15/12944-9, 17/00021-9, 20/11182-6, 20/02469-0, 16/01735-2)
CUNHA, LIA; LUCHS, ADRIANA; AZEVEDO, LAIS S. S.; SILVA, VANESSA C. M.; LEMOS, MARCILIO F. F.; COSTA, ANTONIO C. C.; COMPRI, ADRIANA P. P.; FRANCA, YASMIN; VIANA, ELLEN; MALTA, FERNANDA; et al. Detection of Hepatitis E Virus Genotype 3 in Feces of Capybaras (Hydrochoeris hydrochaeris) in Brazil. Viruses-Basel, v. 15, n. 2, p. 13-pg., . (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)
ARANHA WATANABE, ARIPUANA SAKURADA; LUCHS, ADRIANA; LEAL, ELCIO; DE PADUA MILAGRES, FLAVIO AUGUSTO; KOMNINAKIS, SHIRLEY VASCONCELOS; GILL, DANIELLE ELISE; BRITO SAYAO LOBATO, MARCIA CRISTINA ALVES; BRUSTULIN, RAFAEL; DAS CHAGAS, ROGERIO TOGISAKI; NEVES DOS SANTOS ABRAO, MARIA DE FATIMA; et al. Complete Genome Sequences of Six Human Bocavirus Strains from Patients with Acute Gastroenteritis in the North Region of Brazil. GENOME ANNOUNCEMENTS, v. 6, n. 17, p. 2-pg., . (16/01735-2, 17/00021-9, 15/12944-9)
AZEVEDO, LAIS SAMPAIO; COSTA, FERNANDA FARIA; GHANI, MONIQUE BEERENS ABDUL; VIANA, ELLEN; FRANCA, YASMIN; MEDEIROS, ROBERTA SALZONE; GUIDUCCI, RAQUEL; MORILLO, SIMONE GUADAGNUCCI; PRIMO, DIELI; LOPES, RICARDO DUARTE; et al. Full genotype characterization of Brazilian canine G3P[3] strains during a 10-year survey (2012-2021) of rotavirus infection in domestic dogs and cats. ARCHIVES OF VIROLOGY, v. 168, n. 7, p. 15-pg., . (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)

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