Full genotype constellation of five rare G12P[9] rotavirus strains detected in Brazil during 2011-2013

• Grant number: 20/02469-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2020
• End date: May 31, 2021
• Field of knowledge: Health Sciences - Collective Health - Public Health
• Principal Investigator: Adriana Luchs
• Grantee: Yasmin França Viana Pires de Souza
• Host Institution: Instituto Adolfo Lutz (IAL). Coordenadoria de Controle de Doenças (CCD). Secretaria da Saúde (São Paulo - Estado). São Paulo , SP, Brazil

Abstract

Group A rotaviruses (RVA) are the main cause of acute viral gastroenteritis in both humans and animal. In the last decade, global surveillance of circulating RVA in the human population has revealed the presence of several uncommon genotypes, including Brazil. Many of these have been found in domestic animals, and phylogenetic analysis suggests that they arose in the human population through zoonotic transmission. The distribution and evolution of human RVA strains is important for vaccine development and effectiveness. In setting where RVA vaccine coverage is high, such as in Brazil, vaccine pressure could select for replacement of common strains with uncommon strains, some of which could be generated by reassortment between human and animal RVA. The detection of unusual/rare G and P genotypes association strongly suggest interspecies transmission. Tracking virus evolution and gaining an understanding of the role that animal RVA strains play is important for continued development of vaccine strategies and genotyping surveillance. Monitoring of RVA in the last 10 years (2009-2019) has allowed the identification of 5 rare RVA G12P[9] strains. VP7 (G) and VP4 (P) analysis only cannot determine the exact origin of these strains, and whether these infections were caused by zoonotic transmission. Only genotyping all 11 segments of RVA (genomic constellation) can clarify these issues. The aim of this study is to carry out sequence analysis of the 11 segments of five RVA G12P[9] detected during 2011-2013 in order to obtain further information on the genetic relationship between human and animal RVA.

Scientific publications

(7)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MEDEIROS, ROBERTA SALZONE; FRANCA, YASMIN; VIANA, ELLEN; DE AZEVEDO, LAIS SAMPAIO; GUIDUCCI, RAQUEL; DE LIMA NETO, DANIEL FERREIRA; DA COSTA, ANTONIO CHARLYS; LUCHS, ADRIANA. Genomic Constellation of Human Rotavirus G8 Strains in Brazil over a 13-Year Period: Detection of the Novel Bovine-like G8P[8] Strains with the DS-1-like Backbone. Viruses-Basel, v. 15, n. 3, p. 34-pg., 2023-03-01. (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)

ADRIANA LUCHS; LAIS SAMPAIO DE AZEVEDO; ELLEN VIANA DE SOUZA; ROBERTA SALZONE MEDEIROS; YASMIN FRANÇA VIANA PIRES DE SOUZA; DALANE LOUDAL FLORENTINO TEIXEIRA; THIAGO FRANCO DE OLIVEIRA CARNEIRO; GABRIELA MARIA FERNANDES DE ALENCAR; FERNANDA LÚCIA DE SOUSA LEITE MORAIS; DIANA DE FÁTIMA ALVES PINTO; et al. Coxsackievirus A6 strains causing an outbreak of hand-foot-and-mouth disease in Northeastern Brazil in 2018. Revista do Instituto de Medicina Tropical de São Paulo, v. 64, 2022-02-21. (20/02469-0, 17/00021-9, 19/21706-5, 20/14786-0, 20/11182-6)

DE AZEVEDO, LAIS SAMPAIO; FRANCA, YASMIN; VIANA, ELLEN; MEDEIROS, ROBERTA SALZONE; MORILLO, SIMONE GUADAGNUCCI; GUIDUCCI, RAQUEL; RIBEIRO, CIBELE DANIEL; VIEIRA, HELOISA ROSA; BARRIO-NUEVO, KAROLINA MORALES; CUNHA, MARIANA SEQUETIN; et al. Lack of molecular evidence of fecal-borne viruses in capybaras from Sao Paulo state, Brazil, 2018-2020: a minor public health issue. Brazilian Journal of Microbiology, v. N/A, p. 9-pg., 2022-11-07. (20/14786-0, 20/02469-0, 15/12944-9, 20/11182-6, 19/21706-5)

VIANA PIRES DE SOUZA, YASMIN FRANCA; DE SOUZA, ELLEN VIANA; DE AZEVEDO, LAIS SAMPAIO; MEDEIROS, ROBERTA SALZONE; SAMPAIO TAVARES TIMENETSKY, MARIA DO CARMO; LUCHS, ADRIANA. Enteric adenovirus epidemiology from historical fecal samples in Brazil (1998-2005): Pre-rotavirus vaccine era. INFECTION GENETICS AND EVOLUTION, v. 94, OCT 2021. (20/11182-6, 20/02469-0)

LUCHS, ADRIANA; TARDY, KAELAN; TAHMASEBI, ROOZBEH; MORILLO, SIMONE GUADAGNUCCI; MILAGRES, FLAVIO AUGUSTO DE PADUA; MORAIS, VANESSA DOS SANTOS; BRUSTULIN, RAFAEL; TELES, MARIA DA APARECIDA RODRIGUES; DE AZEVEDO, LAIS SAMPAIO; DE SOUZA, ELLEN VIANA; et al. Human astrovirus types 1, 4 and 5 circulating among children with acute gastroenteritis in a rural Brazilian state, 2010-2016. ARCHIVES OF VIROLOGY, v. 166, n. 11, AUG 2021. (19/21706-5, 15/12944-9, 17/00021-9, 20/11182-6, 20/02469-0, 16/01735-2)

CUNHA, LIA; LUCHS, ADRIANA; AZEVEDO, LAIS S. S.; SILVA, VANESSA C. M.; LEMOS, MARCILIO F. F.; COSTA, ANTONIO C. C.; COMPRI, ADRIANA P. P.; FRANCA, YASMIN; VIANA, ELLEN; MALTA, FERNANDA; et al. Detection of Hepatitis E Virus Genotype 3 in Feces of Capybaras (Hydrochoeris hydrochaeris) in Brazil. Viruses-Basel, v. 15, n. 2, p. 13-pg., 2023-02-01. (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)

AZEVEDO, LAIS SAMPAIO; COSTA, FERNANDA FARIA; GHANI, MONIQUE BEERENS ABDUL; VIANA, ELLEN; FRANCA, YASMIN; MEDEIROS, ROBERTA SALZONE; GUIDUCCI, RAQUEL; MORILLO, SIMONE GUADAGNUCCI; PRIMO, DIELI; LOPES, RICARDO DUARTE; et al. Full genotype characterization of Brazilian canine G3P[3] strains during a 10-year survey (2012-2021) of rotavirus infection in domestic dogs and cats. ARCHIVES OF VIROLOGY, v. 168, n. 7, p. 15-pg., 2023-07-01. (20/02469-0, 15/12944-9, 20/14786-0, 20/11182-6)