Near full length genome of a recombinant (E/D) cosavirus strain from a rural area in the central region of Brazil

Author(s):Show less -

da Costa, Antonio Charlys ^[1] ; Luchs, Adriana ^[2] ; de Padua Milagres, Flavio Augusto ^{[3, 4, 5, 6]} ; Komninakis, Shirley Vasconcelos ^{[7, 8]} ; Gill, Danielle Elise ^[1] ; Brito Sayao Lobato, Marcia Cristina Alves ^{[4, 6]} ; Brustulin, Rafael ^{[4, 5, 6]} ; das Chagas, Rogerio Togisaki ^{[4, 6]} ; Neves dos Santos Abrao, Maria de Fatima ^{[4, 6]} ; de Deus Alves Soares, Cassia Vitoria ^{[4, 6]} ; Deng, Xutao ^{[9, 10]} ; Sabino, Ester Cerdeira ^{[1, 3]} ; Delwart, Eric ^{[9, 10]} ; Leal, Elcio ^[11]

Affiliation:Show less -

^[1] Univ Sao Paulo, Inst Trop Med, Sao Paulo - Brazil

^[2] Adolfo Lutz Inst, Virol Ctr, Enter Dis Lab, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Fac Med, LIM 46, Sao Paulo - Brazil

^[4] Secretary Hlth Tocantins, Tocantins - Brazil

^[5] Fed Univ Tocantins, Tocantins - Brazil

^[6] Publ Hlth Lab Tocantins State LACEN TO, Tocantins - Brazil

^[7] Fac Med ABC, Postgrad Program Hlth Sci, Santo Andre - Brazil

^[8] Univ Fed Sao Paulo, Retrovirol Lab, Sao Paulo, SP - Brazil

^[9] Blood Syst Res Inst, San Francisco, CA - USA

^[10] Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 - USA

^[11] Fed Univ Para, Inst Biol Sci, Belem, Para - Brazil

• Document type: Journal article
• Source: SCIENTIFIC REPORTS; v. 8, AUG 17 2018.
• Web of Science Citations: 4

Abstract

In the present article we report the nearly full length genome of a Cosavirus strain (BRTO-83) isolated from a child with acute gastroenteritis, and who is an inhabitant of a rural area in the central region of Brazil. The sample was previously screened and negative for both: common enteric viruses (i.e. rotavirus and norovirus), bacteria, endoparasites and helminthes. Evolutionary analysis and phylogenetic inferences indicated that the Brazilian BRTO-83 Cosavirus strain was a recombinant virus highly related to the E/D recombinant NG385 strain (Genbank JN867757), which was isolated in Nigeria from an acute flaccid paralysis patient. This is the first report of a recombinant E/D Cosavirus strain detected in Brazil, and the second genome described worldwide. Further surveillance and molecular studies are required to fully understand the epidemiology, distribution and evolution of the Cosavirus. (AU)

• FAPESP's process: 16/01735-2 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil
• Grantee: Ester Cerdeira Sabino
• Support type: Regular Research Grants
• FAPESP's process: 15/12944-9 - Investigating the evoltution of animal rotavirus strains infecting humans
• Grantee: Adriana Luchs
• Support type: Regular Research Grants
• FAPESP's process: 17/00021-9 - Viral metagenomics to track, explain and predict the transmission and spatiotemporal spread of Dengue and Chikungunya viruses in Brazil
• Grantee: Antonio Charlys da Costa
• Support type: Scholarships in Brazil - Post-Doctorate