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Genomic evolution of large DNA viruses of insects

Grant number: 13/15144-8
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): October 10, 2013
Effective date (End): October 09, 2014
Field of knowledge:Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
Principal researcher:Paolo Marinho de Andrade Zanotto
Grantee:Atila Iamarino
Supervisor abroad: Jeffrey Townsend
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Research place: Yale University, United States  
Associated to the scholarship:12/04818-5 - Evolution and phyloynamics of HIV-1 BF recombinants from South America, BP.PD


Large DNA viruses evolve by recombination and by a succession of gene gain and loss events, mostly from cellular host genomes. These processes allow them to undergo necessary adaptive changes. As a consequence, their genome is composed of a common replicative core that holds their evolutionary relationship, around which satellite genes that code mainly for host relationship are accreted. This work aims to compare the genomes of large DNA viruses that infect insects, entomopoxviruses, iridoviruses, ascoviruses, baculoviruses, and nudiviruses; and search for convergent events of independent parallel gene acquisition that may inform about host interaction. These genes will be compared in order to search for evolutionary relation, gene flux, origin, diversification, epistatic interactions and selective pressure after horizontal transfer. While doing so, it will be possible to infer a genomic network that reconstructs events of gene acquisition and modification that could demonstrate how organisms vary their complexity thorough time. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
ZHAO, ZI-MING; ZHAO, BIXIAO; BAI, YALAI; IAMARINO, ATILA; GAFFNEY, STEPHEN G.; SCHLESSINGER, JOSEPH; LIFTON, RICHARD P.; RIMM, DAVID L.; TOWNSEND, JEFFREY P. Early and multiple origins of metastatic lineages within primary tumors. Proceedings of the National Academy of Sciences of the United States of America, v. 113, n. 8, p. 2140-2145, FEB 23 2016. Web of Science Citations: 45.
FREIRE, CAIO C. M.; IAMARINO, ATILA; LY SOUMARE, PEINDA O.; FAYE, OUSMANE; SALL, AMADOU A.; ZANOTTO, PAOLO M. A. Reassortment and distinct evolutionary dynamics of Rift Valley Fever virus genomic segments. SCIENTIFIC REPORTS, v. 5, JUN 23 2015. Web of Science Citations: 9.

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