Evolution and phyloynamics of HIV-1 BF recombinants from South America

• Grant number: 12/04818-5
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: November 01, 2012
• End date: November 30, 2015
• Field of knowledge: Biological Sciences - Genetics - Molecular Genetics and Genetics of Microorganisms
• Principal Investigator: Paolo Marinho de Andrade Zanotto
• Grantee: Atila Iamarino
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
• Associated scholarship(s): 13/15144-8 - Genomic evolution of large DNA viruses of insects, BE.EP.PD

Abstract

HIV-1 BF recombinants play an important role in the South American AIDS epidemic, especially in Brazil and Argentina, and they are recognized by the rapid spread and high replicative capacity. Unlike other epidemics caused by well-established circulating recombinant forms, multiple unique recombinant forms comprise the South American BF recombinants, which result from different recombination events, although they may be miss-classified by their recombination profile. The recombination is an important event for HIV-1 evolution that increases viral fitness, allows immune scape and the emergence of anti-retroviral drug resistance, and may have important epidemiological consequences in places such as Brazil and Argentina, where there is ample therapy prevalence. This works aims to reconsider the classification and number of BF recombinant forms among all available HIV-1 sequences from South America, as well as to estimate the population and evolutionary parameters that allow the understanding of the growth and role of BF recombinants in this regional epidemics. The ancestral relations among common recombinant genomic fragments and selective pressure acting on recurrent regions will also be accessed, which may unravel possible therapeutic targets.

Scientific publications

(5)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FREIRE, CAIO C. M.; IAMARINO, ATILA; LY SOUMARE, PEINDA O.; FAYE, OUSMANE; SALL, AMADOU A.; ZANOTTO, PAOLO M. A.. Reassortment and distinct evolutionary dynamics of Rift Valley Fever virus genomic segments. SCIENTIFIC REPORTS, v. 5, JUN 23 2015. (10/19341-4, 12/04818-5, 13/15144-8, 14/06090-4)

ZHAO, ZI-MING; ZHAO, BIXIAO; BAI, YALAI; IAMARINO, ATILA; GAFFNEY, STEPHEN G.; SCHLESSINGER, JOSEPH; LIFTON, RICHARD P.; RIMM, DAVID L.; TOWNSEND, JEFFREY P.. Early and multiple origins of metastatic lineages within primary tumors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v. 113, n. 8, p. 6-pg., 2016-02-23. (13/15144-8, 12/04818-5)

ZHAO, ZI-MING; ZHAO, BIXIAO; BAI, YALAI; IAMARINO, ATILA; GAFFNEY, STEPHEN G.; SCHLESSINGER, JOSEPH; LIFTON, RICHARD P.; RIMM, DAVID L.; TOWNSEND, JEFFREY P.. Early and multiple origins of metastatic lineages within primary tumors. Proceedings of the National Academy of Sciences of the United States of America, v. 113, n. 8, p. 2140-2145, FEB 23 2016. (12/04818-5, 13/15144-8)

CAIO CÉSAR DE MELO FREIRE; GIUSEPPE PALMISANO; CARLA T BRACONI; FERNANDA R CUGOLA; FABIELE B RUSSO; PATRICIA CB BELTRÃO-BRAGA; ATILA IAMARINO; DANIEL FERREIRA DE LIMA NETO; AMADOU ALPHA SALL; LIVIA ROSA-FERNANDES; et al. NS1 codon usage adaptation to humans in pandemic Zika virus. Memórias do Instituto Oswaldo Cruz, v. 113, n. 5, 2018-05-10. (14/03911-7, 16/03605-9, 14/17766-9, 12/04818-5, 14/06090-4)

FAYE, OUMAR; FREIRE, CAIO C. M.; IAMARINO, ATILA; FAYE, OUSMANE; DE OLIVEIRA, JULIANA VELASCO C.; DIALLO, MAWLOUTH; ZANOTTO, PAOLO M. A.; SALL, AMADOU ALPHA. Molecular Evolution of Zika Virus during Its Emergence in the 20th Century. PLoS Neglected Tropical Diseases, v. 8, n. 1, JAN 2014. (10/19341-4, 12/04818-5)