Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression

Autor(es)

Santos, A. R. ^{[1, 2]} ; Lamas, L. ^[1] ; Ugrinowitsch, C. ^[1] ; Tricoli, V. ^[1] ; Miyabara, E. H. ^[3] ; Soares, A. G. ^[4] ; Aoki, M. S. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-03828000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Arts Sci & Human, BR-03828000 Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, BR-03828000 Sao Paulo - Brazil

^[4] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, BR-03828000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 36, n. 9, p. 761-768, AUG 2015.
• Citações Web of Science: 3

Resumo

The aim of the present study was to investigate the effect of different resistance-training regimens (S or P) on the expression of genes related to the MSTN signaling pathway in physically-active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n=11) or a power-training group (P; n=11). The control group (C; n=7) was composed of healthy physically-active males. The S and the P groups performed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST (S: 4.2 fold induction and P: 3.7 fold induction, p<0.01) and FL-3 (S: 5.6 fold induction and P: 5.6 fold induction, p<0.01), was detected after the training period. SMAD-7 gene expression was similarly augmented after both training protocols (S: 2.5 fold induction; P: 2.8 fold induction; p<0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner. (AU)

• Processo FAPESP: 08/58415-3 - Expressão de genes envolvidos na sinalização da miostatina (GDF-8) em resposta a diferentes modelos de treinamento de força
• Beneficiário: Marcelo Saldanha Aoki
• Linha de fomento: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/52288-7 - Efeito de diferentes protocolos de treinamento de força sobre a expressão de genes da via WNT em humanos
• Beneficiário: Marcelo Larciprete Leal
• Linha de fomento: Bolsas no Brasil - Mestrado
• Processo FAPESP: 06/61523-7 - Aspectos celulares e moleculares da plasticidade muscular
• Beneficiário: Anselmo Sigari Moriscot
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 06/00302-3 - Treinamento força com vibração: análise dos fatores determinantes da melhora no desempenho do salto vertical
• Beneficiário: Carlos Ugrinowitsch
• Linha de fomento: Auxílio à Pesquisa - Regular