Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression

Full text
Author(s):
Santos, A. R. [1, 2] ; Lamas, L. [1] ; Ugrinowitsch, C. [1] ; Tricoli, V. [1] ; Miyabara, E. H. [3] ; Soares, A. G. [4] ; Aoki, M. S. [2]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-03828000 Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Arts Sci & Human, BR-03828000 Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept Anat, Inst Biomed Sci, BR-03828000 Sao Paulo - Brazil
[4] Univ Sao Paulo, Dept Pharmacol, Inst Biomed Sci, BR-03828000 Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF SPORTS MEDICINE; v. 36, n. 9, p. 761-768, AUG 2015.
Web of Science Citations: 3
Abstract

The aim of the present study was to investigate the effect of different resistance-training regimens (S or P) on the expression of genes related to the MSTN signaling pathway in physically-active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n=11) or a power-training group (P; n=11). The control group (C; n=7) was composed of healthy physically-active males. The S and the P groups performed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST (S: 4.2 fold induction and P: 3.7 fold induction, p<0.01) and FL-3 (S: 5.6 fold induction and P: 5.6 fold induction, p<0.01), was detected after the training period. SMAD-7 gene expression was similarly augmented after both training protocols (S: 2.5 fold induction; P: 2.8 fold induction; p<0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner. (AU)

FAPESP's process: 06/00302-3 - Strength training with vibration: analysis of the determinant factors of vertical jump performance improvement
Grantee:Carlos Ugrinowitsch
Support Opportunities: Regular Research Grants
FAPESP's process: 06/61523-7 - Cellular and molecular aspects of muscular plasticity
Grantee:Anselmo Sigari Moriscot
Support Opportunities: Research Projects - Thematic Grants