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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Serum Levels of Cytokines in Subjects With Generalized Chronic and Aggressive Periodontitis Before and After Non-Surgical Periodontal Therapy: A Pilot Study

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Autor(es):
Duarte, Poliana Mendes [1] ; da Rocha, Marcelo [1] ; Sampaio, Eduardo [1] ; Mestnik, Maria Josefa [1] ; Feres, Magda [1] ; Figueiredo, Luciene Cristina [1] ; Bastos, Marta Ferreira [1] ; Faveri, Marcelo [1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] Univ Guarulhos, Dept Periodont, Dent Res Div, Sao Paulo - Brazil
Número total de Afiliações: 1
Tipo de documento: Artigo Científico
Fonte: Journal of Periodontology; v. 81, n. 7, p. 1056-1063, JUL 2010.
Citações Web of Science: 68
Resumo

Background: The emergence of periodontal medicine has increased interest in defining the serologic profiles of inflammatory mediators in subjects with periodontais. Thus, the aim of this pilot study is to evaluate the serum levels of tumor necrosis factor-alpha (TNF-alpha), interferon--gamma, and interleukin (IL)-4, -17, and -23 in subjects with generalized chronic periodontitis (GCP) and generalized aggressive periodontitis (GAgP) before and after non-surgical periodontal therapy. Methods: Cytokines were measured by enzyme-linked immunosorbent assay in serum samples taken from 42 systemically healthy subjects divided according to periodontal status into subjects with GAgP (n = 14) and GCP (n = 14) and periodontally healthy (PH) subjects (n = 14). In addition, the levels of cytokines were reassessed at 6 months after periodontal therapy in the periodontitis groups. Clinical parameters were also evaluated at baseline and 6 months post-therapy. Results: After therapy, both periodontitis groups demonstrated a significant improvement in clinical periodontal status (P <0.05). At baseline, concentrations of TNF-alpha (P = 0.0006) and IL-17 (P = 0.02) were significantly higher in the GAgP group compared to the other groups. There was a significant decrease in serum concentrations of TNF-alpha (P = 0.03) and IL-17 (P = 0.04) at 6 months post-therapy in the GAgP group (P <0.05). The concentration of TNF-alpha remained elevated in the GAgP group compared to the PH group at 6 months post-therapy (P = 0.04). Conclusions: Subjects with GAgP presented higher levels of TNF-alpha and IL-17 than subjects with GCP and PH subjects. In addition, although the serum levels of these cytokines improved significantly as a result of periodontal therapy, the levels of TNF-alpha remained higher in subjects with GAgP compared to PH subjects. J Periodontol 2010;81:1056-1063, (AU)

Processo FAPESP: 07/56413-0 - Efeitos clínicos e microbiológicos da associação sistêmica de amoxicilina e metronidazol à raspagem e alisamento radicular em indivíduos com doença periodontal agressiva generalizada
Beneficiário:Marcelo de Faveri
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/09687-0 - Tratamento periodontal em indivíduos diabéticos compensados e não-compensados portadores de Diabetes Mellitus: avaliação clínica, glicêmica e dos níveis de citocinas e fatores de reabsorção óssea
Beneficiário:Poliana Mendes Duarte
Linha de fomento: Auxílio à Pesquisa - Regular