ABO blood group in primary antiphospholipid syndrome: influence in the site of thrombosis?

Autor(es)

Nascimento, Natalia Mastantuono ^[1] ; Bydlowski, Sergio Paulo ^[1] ; Silva Soares, Rosangela Paula ^[2] ; Oliveira de Andrade, Danieli Castro ^[3] ; Bonfa, Eloisa ^[3] ; Costa Seguro, Luciana Parente ^[3] ; Borba, Eduardo Ferreira ^[3]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Lab Genet & Mol Hematol LIM 31, BR-05403000 Sao Paulo, SP - Brazil

^[2] Fundacao Prosangue Hemocentro Sao Paulo, BR-05403000 Sao Paulo, SP - Brazil

^[3] Univ Sao Paulo, Sch Med, Div Rheumatol, BR-01246903 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF THROMBOSIS AND THROMBOLYSIS; v. 40, n. 3, p. 374-378, OCT 2015.
• Citações Web of Science: 3

Resumo

Antiphospholipid syndrome (APS) is characterized by vascular thrombosis and/or obstetric complications associated with presence of antiphospholipid antibodies (aPL) but additional factors would also induce thrombosis. ABO (H) blood groups are known to be closely related to thrombosis, especially non-O blood type with venous events. The aim of this study was to investigate possible role of ABO (H) blood types in the thrombotic events in primary APS (PAPS). Seventy PAPS patients were selected for the study and were divided according to ABO blood group in: O PAPS (n = 26) and non-O PAPS (n = 44). ABO blood group phenotyping was performed by indirect technique. aPL anticardiolipin (aCL) and anti-beta eta2 glycoprotein-1 (a beta 2GPI) and the concentrations and activities of von Willebrand factor (VWF) were measured with ELISA. Lupus anticoagulant (LA) was detected by coagulation assays. A significant higher frequency of venous events was observed in non-O PAPS group (72.7 vs. 46.2 %, p = 0.040). In contrast, the frequency of arterial events was significantly higher in the O PAPS compared to the non-O PAPS group (69.2 vs. 36.4 %, respectively; p = 0.013). Frequencies of aCL, LA, a beta 2GPI and triple aPL positivity were similar in both groups (p > 0.05). VWF antigen (75.54 +/- A 8.68 vs. 79.51 +/- A 7.07 IU/dl, p = 0.041) and activity (70.23 +/- A 11.96 vs. 77.92 +/- A 13.67 %, p = 0.020) were decreased in O PAPS compared to non-O blood group. VWF:CB/VWF:Ag ratio was similar among groups (p > 0.05). This is the first report that confirms the role of ABO blood system in thrombosis of PAPS and suggests that non-O blood group was related with venous events and O blood group with arterial thrombosis. (AU)

• Processo FAPESP: 13/02785-5 - Estudo da disfunção endotelial e hemostática em pacientes com síndrome antifosfolípide primária
• Beneficiário: Rosangela de Paula Silva Soares
• Modalidade de apoio: Auxílio à Pesquisa - Regular