Phosphatidylglycerol-derived phospholipids have a universal, domain-crossing role in stress responses

Autor(es)

Luevano-Martinez, Luis Alberto ^[1] ; Kowaltowski, Alicia J. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Bioquim, Inst Quim, BR-05508 Sao Paulo, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Archives of Biochemistry and Biophysics; v. 585, p. 90-97, NOV 1 2015.
• Citações Web of Science: 8

Resumo

Phosphatidylglycerol and phospholipids derived from it are widely distributed throughout the three domains of life. Cardiolipin is the best characterized of these phospholipids, and plays a key role in the response to environmental variations. Phosphatidylglycerol-derived phospholipids confer cell membranes with a wide range of responses, including changes in surface charge, fluidity, flexibility, morphology, biosynthesis and remodeling, that adapt the cell to these situations. Furthermore, the synthesis and remodeling of these phospholipids is finely regulated, highlighting the importance of these lipids in cell homeostasis and responses during stressful situations. In this article, we review the most important roles of these anionic phospholipids across domains, focusing on the biophysical basis by which these phospholipids are used in stress responses. (C) 2015 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 13/04919-9 - Avaliação da resposta adaptativa das membranas mitocondriais em situações de estresse: papel da cardiolipina na plasticidade da membrana, dinâmica e situações patológicas
• Beneficiário: Luis Alberto Luevano Martinez
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/07937-8 - Redoxoma
• Beneficiário: Ohara Augusto
• Modalidade de apoio: Auxílio à Pesquisa - Centros de Pesquisa, Inovação e Difusão - CEPIDs