Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea

Autor(es)

Drager, Luciano F. ^{[1, 2]} ; Polotsky, Vsevolod Y. ^[3] ; O'Donnell, Christopher P. ^[4] ; Cravo, Sergio L. ^[5] ; Lorenzi-Filho, Geraldo ^[6] ; Machado, Benedito H. ^[7]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Med, Heart Inst InCor, Hypertens Unit, BR-05403900 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Med, Div Renal, Hypertens Unit, BR-05403900 Sao Paulo - Brazil

^[3] Johns Hopkins Univ, Sch Med, Div Pulm & Crit Care Med, Baltimore, MD - USA

^[4] Univ Pittsburgh, Dept Med, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA - USA

^[5] Univ Fed Sao Paulo, Escola Paulista Med, Dept Physiol, Sao Paulo - Brazil

^[6] Univ Sao Paulo, Sch Med, Heart Inst InCor, Div Pulm, Sleep Lab, BR-05403900 Sao Paulo - Brazil

^[7] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Physiol, BR-05403900 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY; v. 309, n. 7, p. H1101-H1111, OCT 1 2015.
• Citações Web of Science: 39

Resumo

Obstructive sleep apnea (OSA) is known to be independently associated with several cardiovascular diseases including hypertension, myocardial infarction, and stroke. To determine how OSA can increase cardiovascular risk, animal models have been developed to explore the underlying mechanisms and the cellular and end-organ targets of the predominant pathophysiological disturbance in OSA-intermittent hypoxia. Despite several limitations in translating data from animal models to the clinical arena, significant progress has been made in our understanding of how OSA confers increased cardiovascular risk. It is clear now that the hypoxic stress associated with OSA can elicit a broad spectrum of pathological systemic events including sympathetic activation, systemic inflammation, impaired glucose and lipid metabolism, and endothelial dysfunction, among others. This review provides an update of the basic, clinical, and translational advances in our understanding of the metabolic dysfunction and cardiovascular consequences of OSA and highlights the most recent findings and perspectives in the field. (AU)

• Processo FAPESP: 12/02953-2 - Impacto da apneia obstrutiva do sono e da duração do sono sobre a progressão das doenças cardiovasculares
• Beneficiário: Luciano Ferreira Drager
• Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores
• Processo FAPESP: 13/06077-5 - Alterações nas redes neurais envolvidas na geração e controle das atividades simpática e respiratória em diferentes modelos experimentais de hipóxia
• Beneficiário: Benedito Honorio Machado
• Linha de fomento: Auxílio à Pesquisa - Temático