Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives

Autor(es)

de Melo Burger, Marcela Carmen ^[1] ; Terezan, Ana Paula ^[2] ; de Oliveira Cunha, Gracielle Silva ^[1] ; Fernandes, Joao Batista ^[2] ; das Gracas Fernandes da Silva, Maria Fatima ^[2] ; Vieira, Paulo Cezar ^[2] ; Severo Menezes, Antonio Carlos ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Goias, Unidade Univ Ciencias Exatas & Tecnol, Lab Anal Instrumental, Anapolis, Go - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, Lab Prod Nat, BR-13560 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 25, n. 5, p. 451-454, SEP-OCT 2015.
• Citações Web of Science: 2

Resumo

ABSTRACTThe antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. & Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa. (AU)

• Processo FAPESP: 06/58043-3 - Controle de formigas cortadeiras, estudos integrados
• Beneficiário: João Batista Fernandes
• Modalidade de apoio: Auxílio à Pesquisa - Temático