Antimicrobial activity of the myrsinoic acid A from Myrsine coriacea and the semi-synthetic derivatives

Author(s)

de Melo Burger, Marcela Carmen ^[1] ; Terezan, Ana Paula ^[2] ; de Oliveira Cunha, Gracielle Silva ^[1] ; Fernandes, Joao Batista ^[2] ; das Gracas Fernandes da Silva, Maria Fatima ^[2] ; Vieira, Paulo Cezar ^[2] ; Severo Menezes, Antonio Carlos ^[1]

Affiliation

^[1] Univ Estadual Goias, Unidade Univ Ciencias Exatas & Tecnol, Lab Anal Instrumental, Anapolis, Go - Brazil

^[2] Univ Fed Sao Carlos, Dept Quim, Lab Prod Nat, BR-13560 Sao Carlos, SP - Brazil

• Document type: Journal article
• Source: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 25, n. 5, p. 451-454, SEP-OCT 2015.
• Web of Science Citations: 2

Abstract

ABSTRACTThe antimicrobial activity of the myrsinoic acid A isolated from Myrsine coriacea (Sw.) R.Br. ex Roem. & Schult., Primulaceae, and a two semi-synthetics derivatives was tested against Bacillus subtilis, Escherichia coli, Salmonella enterica subsp. enterica serovar typhi, Staphylococcus aureus, Streptococcus pyogenes, Pseudomonas aeruginosa, Micrococcus luteus, Candida albicans, Candida krusei and Candida tropicalis. The microdilution method was used for the determination of the minimum inhibitory concentration during evaluation of the antimicrobial activity. The myrsinoic acid A showed no activity against the selected microorganisms but the hydrogenated and acetylated derivatives were active against B. subtilis, E. coli, S. aureus and P. aeruginosa. (AU)

• FAPESP's process: 06/58043-3 - Leaf cutting ants control, integrated studies
• Grantee: João Batista Fernandes
• Support Opportunities: Research Projects - Thematic Grants