Scientific evidence for health effects attributed to the consumption of probiotics and prebiotics: an update for current perspectives and future challenges

Autor(es)

Ruiz Martinez, Rafael Chacon ^[1] ; Bedani, Raquel ^[2] ; Isay Saad, Susana Marta ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Food & Expt Nutr, BR-05508000 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, BR-05508000 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: BRITISH JOURNAL OF NUTRITION; v. 114, n. 12, p. 1993-2015, DEC 28 2015.
• Citações Web of Science: 43

Resumo

Probiotics and prebiotics, mainly commercialised as food ingredients and also as supplements, are considered highly profitable niche markets. However, in recent years, the food industry has suffered from a series of health claim restrictions on probiotics and prebiotics in many parts of the world, including those made by the European Food Safety Authority. Therefore, we reviewed the core benefits of probiotic and prebiotic consumption on health. A number of studies have examined the prevention and/or management of intestinal infections, respiratory tract infections, CVD, osteoporosis, urogenital infections, cavities, periodontal disease and halitosis, allergic reactions, inflammatory bowel disease and irritable bowel syndrome and Helicobacter pylori gastric infections. In fact, a deeper understanding of the mechanisms involved in human microbiota and immune system modulation by probiotics and prebiotics relies on continuous efforts to establish suitable biomarkers of health and diseases risk factors for the design of clinical trials required for health claim approval. In spite of the promising results, the performance of large, long-term, well-planned, well-aligned clinical studies is crucial to provide more reliability and a more solid basis for the outcomes achieved and to support the potential use of probiotics and prebiotics in clinical practice. (AU)

• Processo FAPESP: 10/52267-2 - Abordagem bioquimico-molecular para avaliacao da bacteriocinogenese e do controle de listeria monocytogenes por lactobacillus sakei 2a em um produto lacteo simbiotico potencialmente funcional.
• Beneficiário: Rafael Chacon Ruiz Martinez
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 13/50506-8 - Bioactive components from by-products of food processing used in a symbiotic approach for improving human health and well-being (BioSyn)
• Beneficiário: Susana Marta Isay Saad
• Modalidade de apoio: Auxílio à Pesquisa - Temático
• Processo FAPESP: 09/51169-0 - Desenvolvimento de um iogurte de soja probiótico enriquecido com cálcio e suplementado com inulina e farinha de okara: resistência dos probióticos in vitro e influência sobre os marcadores laboratoriais de risco para aterosclerose em humanos
• Beneficiário: Susana Marta Isay Saad
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 09/51168-3 - Desenvolvimento de um iogurte de soja probiótico enriquecido com cálcio e suplementado com inulina e farinha de okara: resistência dos probióticos in vitro e influência sobre os marcadores laboratoriais de risco para aterosclerose em humanos
• Beneficiário: Raquel Bedani Salvio
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado