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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions

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Autor(es):
Dornellas, A. P. S. [1] ; Watanabe, R. L. H. [1] ; Pimentel, G. D. [1] ; Boldarine, V. T. [1] ; Nascimento, C. M. O. [1] ; Oyama, L. M. [1] ; Ghebremeskel, K. [2] ; Wang, Y. [3] ; Bueno, A. A. [4] ; Ribeiro, E. B. [1]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Fed Sao Paulo, Div Nutr Physiol, Dept Physiol, BR-04023062 Sao Paulo, SP - Brazil
[2] London Metropolitan Univ, Fac Life Sci & Comp, Lipid & Nutr Res Ctr, London - England
[3] Univ London Imperial Coll Sci Technol & Med, Inst Reprod & Dev Biol, Paediat Sect, Dept Med, Div Infect Dis, London - England
[4] Univ Worcester, Inst Sci & Environm, Worcester, MA - USA
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS; v. 102, p. 21-29, DEC 2015.
Citações Web of Science: 5
Resumo

Altered tissue fatty acid (FA) composition may affect mechanisms involved in the control of energy homeostasis, including central insulin actions. In rats fed either standard chow or a lard-enriched chow (high in saturated/low in polyunsaturated FA, HS-LP) for eight weeks, we examined the FA composition of blood, hypothalamus, liver, and retroperitoneal, epididymal and mesenteric adipose tissues. Insulin-induced hypophagia and hypothalamic signaling were evaluated after intracerebroventricular insulin injection. HS-LP feeding increased saturated FA content in adipose tissues and serum while it decreased polyunsaturated FA content of adipose tissues, serum, and liver. Hypothalamic C20:5n-3 and C20:3n-6 contents increased while monounsaturated FA content decreased. HS-LP rats showed hyperglycemia, impaired insulin-induced hypophagia and hypothalamic insulin signaling. The results showed that, upon HS-LP feeding, peripheral tissues underwent potentially deleterious alterations in their FA composition, whist the hypothalamus was relatively preserved. However, hypothalamic insulin signaling and hypophagia were drastically impaired. These findings suggest that impairment of hypothalamic insulin actions by HS-LP feeding was not related to tissue FA composition. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

Processo FAPESP: 07/05360-4 - Efeito do consumo prolongado de diferentes dietas hiperlipídicas sobre o controle central da ingestão alimentar em ratos
Beneficiário:Eliane Beraldi Ribeiro
Linha de fomento: Auxílio à Pesquisa - Regular