Antimalarial Effect of 3-Methoxy-1,2-Dioxetanes on the Erythrocytic Cycle of Plasmodium falciparum

Autor(es)

Lopes, Nicolas S. ^[1] ; Yoshitake, Ariane M. ^[1] ; Silva, Adriana F. ^[1] ; Oliveira, Jr., Vani X. ^[1] ; Silva, Leandro S. ^[2] ; Pinheiro, Ana A. S. ^[2] ; Ciscato, Luiz Francisco M. L. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil

^[2] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21944970 Rio De Janeiro, RJ - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CHEMICAL BIOLOGY & DRUG DESIGN; v. 86, n. 6, p. 1373-1377, DEC 2015.
• Citações Web of Science: 6

Resumo

The antimalarial activity of peroxides most likely originates from their interaction with iron(II) species located inside the malaria parasite, which forms destructive radical species through a Fenton-like mechanism. This article reports the first evaluation of the in vitro antimalarial activity of three peroxides of the class 1,2-dioxetanes against Plasmodium falciparum; the results reveal that the studied 3-methoxy-1,2-dioxetanes display significant antimalarial activity, at a similar level as artemisinin and also that their reactivity toward iron (II) correlate linearly with their antimalarial activity. (AU)

• Processo FAPESP: 12/02428-5 - Peróxidos orgânicos cíclicos: síntese e mecanismo de redução
• Beneficiário: Luiz Francisco Monteiro Leite Ciscato
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 11/10823-9 - Compostos antimaláricos derivados da angiotensina II
• Beneficiário: Vani Xavier de Oliveira Junior
• Modalidade de apoio: Auxílio à Pesquisa - Regular