| Full text | |
| Author(s): |
Lopes, Nicolas S.
[1]
;
Yoshitake, Ariane M.
[1]
;
Silva, Adriana F.
[1]
;
Oliveira, Jr., Vani X.
[1]
;
Silva, Leandro S.
[2]
;
Pinheiro, Ana A. S.
[2]
;
Ciscato, Luiz Francisco M. L.
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP - Brazil
[2] Univ Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21944970 Rio De Janeiro, RJ - Brazil
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | CHEMICAL BIOLOGY & DRUG DESIGN; v. 86, n. 6, p. 1373-1377, DEC 2015. |
| Web of Science Citations: | 6 |
| Abstract | |
The antimalarial activity of peroxides most likely originates from their interaction with iron(II) species located inside the malaria parasite, which forms destructive radical species through a Fenton-like mechanism. This article reports the first evaluation of the in vitro antimalarial activity of three peroxides of the class 1,2-dioxetanes against Plasmodium falciparum; the results reveal that the studied 3-methoxy-1,2-dioxetanes display significant antimalarial activity, at a similar level as artemisinin and also that their reactivity toward iron (II) correlate linearly with their antimalarial activity. (AU) | |
| FAPESP's process: | 12/02428-5 - Cyclic organic peroxides: synthesis and mechanism of reduction |
| Grantee: | Luiz Francisco Monteiro Leite Ciscato |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 11/10823-9 - Antimalarial compounds derivative from angiotensin II |
| Grantee: | Vani Xavier de Oliveira Junior |
| Support Opportunities: | Regular Research Grants |