| Texto completo | |
| Autor(es): Mostrar menos - |
Goya, Thiago T.
[1]
;
Silva, Rosyvaldo F.
[2]
;
Guerra, Renan S.
[3]
;
Lima, Marta F.
[3]
;
Barbosa, Eline R. F.
[3]
;
Cunha, Paulo Jannuzzi
[4, 5]
;
Lobo, Denise M. L.
[3]
;
Buchpiguel, Carlos A.
[6]
;
Busatto-Filho, Geraldo
[4, 5]
;
Negrao, Carlos E.
[7, 3]
;
Lorenzi-Filho, Geraldo
[3]
;
Ueno-Pardi, Linda M.
[2, 4]
Número total de Autores: 12
|
| Afiliação do(s) autor(es): | [1] HCFMUSP, Master Program Expt Physiopathol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo - Brazil
[3] InCor HCFMUSP, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-03828000 Sao Paulo - Brazil
[5] HCFMUSP, Dept Psychiat, Lab Psychiat Neuroimaging, Sao Paulo - Brazil
[6] HCFMUSP, Inst Radiol, Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Phys Educ & Sport, BR-03828000 Sao Paulo - Brazil
Número total de Afiliações: 7
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Sleep; v. 39, n. 1, p. 25-33, JAN 1 2016. |
| Citações Web of Science: | 9 |
| Resumo | |
Study Objectives: To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA). Methods: Individuals with no other comorbidities (age = 52 +/- 1 y, body mass index = 29 +/- 0.4, kg/m(2)) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT. Results: Control and OSA groups (apnea-hypopnea index, AHI = 8 +/- 1 and 47 +/- 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O-2 saturation (r = -0.57). Conclusions: As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress. (AU) | |
| Processo FAPESP: | 10/15064-6 - Efeitos do treinamento físico na estrutura e metabolismo cerebral, cognição e controle neurovascular em indivíduos com apnéia obstrutiva do sono |
| Beneficiário: | Linda Massako Ueno Pardi |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |