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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea

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Author(s):
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Goya, Thiago T. [1] ; Silva, Rosyvaldo F. [2] ; Guerra, Renan S. [3] ; Lima, Marta F. [3] ; Barbosa, Eline R. F. [3] ; Cunha, Paulo Jannuzzi [4, 5] ; Lobo, Denise M. L. [3] ; Buchpiguel, Carlos A. [6] ; Busatto-Filho, Geraldo [4, 5] ; Negrao, Carlos E. [7, 3] ; Lorenzi-Filho, Geraldo [3] ; Ueno-Pardi, Linda M. [2, 4]
Total Authors: 12
Affiliation:
[1] HCFMUSP, Master Program Expt Physiopathol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Escola Artes Ciencias & Humanidades, BR-03828000 Sao Paulo - Brazil
[3] InCor HCFMUSP, Sao Paulo - Brazil
[4] Univ Sao Paulo, Ctr Interdisciplinary Res Appl Neurosci NAPNA, BR-03828000 Sao Paulo - Brazil
[5] HCFMUSP, Dept Psychiat, Lab Psychiat Neuroimaging, Sao Paulo - Brazil
[6] HCFMUSP, Inst Radiol, Sao Paulo - Brazil
[7] Univ Sao Paulo, Sch Phys Educ & Sport, BR-03828000 Sao Paulo - Brazil
Total Affiliations: 7
Document type: Journal article
Source: Sleep; v. 39, n. 1, p. 25-33, JAN 1 2016.
Web of Science Citations: 9
Abstract

Study Objectives: To investigate muscle sympathetic nerve activity (MSNA) response and executive performance during mental stress in obstructive sleep apnea (OSA). Methods: Individuals with no other comorbidities (age = 52 +/- 1 y, body mass index = 29 +/- 0.4, kg/m(2)) were divided into two groups: (1) control (n = 15) and (2) untreated OSA (n = 20) defined by polysomnography. Mini-Mental State of Examination (MMSE) and Inteligence quocient (IQ) were assessed. Heart rate (HR), blood pressure (BP), and MSNA (microneurography) were measured at baseline and during 3 min of the Stroop Color Word Test (SCWT). Sustained attention and inhibitory control were assessed by the number of correct answers and errors during SCWT. Results: Control and OSA groups (apnea-hypopnea index, AHI = 8 +/- 1 and 47 +/- 1 events/h, respectively) were similar in age, MMSE, and IQ. Baseline HR and BP were similar and increased similarly during SCWT in control and OSA groups. In contrast, baseline MSNA was higher in OSA compared to controls. Moreover, MSNA significantly increased in the third minute of SCWT in OSA, but remained unchanged in controls (P < 0.05). The number of correct answers was lower and the number of errors was significantly higher during the second and third minutes of SCWT in the OSA group (P < 0.05). There was a significant correlation (P < 0.01) between the number of errors in the third minute of SCWT with AHI (r = 0.59), arousal index (r = 0.55), and minimum O-2 saturation (r = -0.57). Conclusions: As compared to controls, MSNA is increased in patients with OSA at rest, and further significant MSNA increments and worse executive performance are seen during mental stress. (AU)

FAPESP's process: 10/15064-6 - Effects of exercise training on structure and cerebral metabolism, cognition and neurovascular control in individuals with obstructive sleep apnea
Grantee:Linda Massako Ueno Pardi
Support Opportunities: Regular Research Grants