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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

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Autor(es):
Anbinder, Ana Lia [1] ; Moraes, Renata M. [1] ; Lima, Gabriela M. G. [1] ; Oliveira, Felipe E. [1] ; Campos, Debora R. C. [1] ; Rossoni, Rodnei D. [1] ; Oliveira, Luciane D. [1] ; Junqueira, Juliana C. [1] ; Ma, Yun [2, 3] ; Elefteriou, Florent [2, 3]
Número total de Autores: 10
Afiliação do(s) autor(es):
[1] Univ Estadual Paulista UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Biosci & Oral Diag, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Paulo - Brazil
[2] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Bone Biol, Dept Med, Dept Pharmacol, Nashville, TN 37215 - USA
[3] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37215 - USA
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: BONE; v. 83, p. 241-247, FEB 2016.
Citações Web of Science: 10
Resumo

Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48 days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP + OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-alpha than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies. (c) 2015 Elsevier Inc. All rights reserved. (AU)

Processo FAPESP: 12/23825-2 - Efeitos da doença periodontal na remodelação óssea sistêmica em camundongos
Beneficiário:Ana Lia Anbinder
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 13/00718-9 - Efeito da doença periodontal na remodelação óssea em fêmur de camundongos ovariectomizados: estudo microtomográfico
Beneficiário:Débora Reis Cleto Campos
Linha de fomento: Bolsas no Brasil - Iniciação Científica