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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Periodontal disease exacerbates systemic ovariectomy-induced bone loss in mice

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Anbinder, Ana Lia [1] ; Moraes, Renata M. [1] ; Lima, Gabriela M. G. [1] ; Oliveira, Felipe E. [1] ; Campos, Debora R. C. [1] ; Rossoni, Rodnei D. [1] ; Oliveira, Luciane D. [1] ; Junqueira, Juliana C. [1] ; Ma, Yun [2, 3] ; Elefteriou, Florent [2, 3]
Total Authors: 10
[1] Univ Estadual Paulista UNESP, Inst Sci & Technol Sao Jose dos Campos, Dept Biosci & Oral Diag, Ave Engn Francisco Jose Longo 777, BR-12245000 Sao Paulo - Brazil
[2] Vanderbilt Univ, Med Ctr, Vanderbilt Ctr Bone Biol, Dept Med, Dept Pharmacol, Nashville, TN 37215 - USA
[3] Vanderbilt Univ, Med Ctr, Dept Canc Biol, Nashville, TN 37215 - USA
Total Affiliations: 3
Document type: Journal article
Source: BONE; v. 83, p. 241-247, FEB 2016.
Web of Science Citations: 8

Periodontal pathogens and/or inflammatory products from periodontitis participate in the development or progression of systemic diseases. In this context, periodontitis acts as a modifying factor to systemic health, including diabetes and cardiovascular diseases. Osteoporosis is an increasingly prevalent condition in our aging population and considered a risk factor for periodontal disease, but the effect of periodontitis on systemic bone homeostasis is unknown. We thus evaluated the effects of experimental periodontitis (EP) on systemic bone loss and the influence of estrogen deficiency in this context, using a mouse model of combined periodontitis and osteoporosis. Experimental periodontitis (EP) was induced by a ligature insertion around the mandibular first molars and Porphyromonas gingivalis infection. Three-dimensional microcomputed tomographic analyses performed 48 days following infection revealed that EP and ovariectomy (OVX) induced a significantly higher femoral and mandibular bone loss compared to EP or OVX alone. EP alone did not induce systemic bone loss. In addition, the EP + OVX and EP groups showed significantly higher levels of tumor necrosis factor (TNF)-alpha than OVX and control groups at end point. These results suggest that periodontitis could be a risk factor for systemic bone loss, especially in post-menopausal women, and warrant further clinical investigations to confirm this association and propose adapted prophylactic and curative therapies. (c) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/23825-2 - Effects of periodontal disease on systemic bone remodeling in mice
Grantee:Ana Lia Anbinder
Support type: Regular Research Grants
FAPESP's process: 13/00718-9 - Effects of periodontal disease on femoral bone remodeling in ovariectomized mice: a tomographic study
Grantee:Débora Reis Cleto Campos
Support type: Scholarships in Brazil - Scientific Initiation