Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, Sao Paulo, Brazil

Autor(es)

de Souza, Wysllenny N. ^[1] ; Norde, Marina M. ^[1] ; Oki, Erica ^[1] ; Rogero, Marcelo M. ^[1] ; Marchioni, Dirce M. L. ^[1] ; Fisberg, Regina M. ^[1] ; Martini, Ligia A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Nutrition Research; v. 36, n. 1, p. 1-8, JAN 2016.
• Citações Web of Science: 8

Resumo

Besides the classic vitamin D function on bone homeostasis, there are bodies of evidence showing that adequate status of vitamin D can modulate inflammation. We hypothesized that higher plasma levels of 25-hydroxyvitamin D (25{[}OH]D) would correlate with lower plasma levels of proinflammatory cytokines, acute-phase proteins, and soluble adhesion molecules and higher plasma levels of anti-inflammatory cytokines. We included all adults (age, 20-59 years) of the population-based, cross-sectional study, Health Survey-Sao Paulo, conducted in Sao Paulo (Brazil) in the study (n = 281). Anthropometric parameters, blood pressure measurements, and a fasting blood sample were collected by trained fieldworkers. Serum 25(OH)D concentration, plasma inflammatory biomarker levels (C-reactive protein, interleukin {[}IL]-1 beta, IL-6, IL-8, IL-10, tumor necrosis factor {[}TNF] alpha, IL-12p70, adiponectin, monocyte chemoattractant protein-1, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1), and plasma blood lipid parameters were evaluated. The prevalence of vitamin D inadequacy (<50 nmol/L) was 65.5%. Inadequate participants were younger, with lower body mass index (BMI), systolic and diastolic blood pressures, triglyceride, and total cholesterol levels as well as low-density lipoprotein cholesterol, compared with individuals adequate for vitamin D status. After adjustment, plasma concentration of soluble intercellular adhesion molecule-1 was statistically higher among adequate participants. Stratifying for BMI categories, a negative association was observed between plasma IL-6 and TNF-alpha levels and serum 25(OH)D concentration in normal-weight participants, whereas a negative association was detected between plasma adiponectin level and serum 25(OH)D concentration in overweight participants. The present findings suggest that BMI interacts with serum 25(OH)D levels, modulating inflammatory response and affecting plasma IL-6, TNF-alpha, and adiponectin levels. These data indicate that BMI plays a determinant role in the vitamin D-inflammation axis. (C) 2016 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 12/20401-7 - Associação entre SNP relacionados aos genes da adiponectina, proteína C reativa, TLR4, TNF-alfa, IL-1 beta, IL-6 e IL-10 e ingestão de lipídios e seus efeitos sobre a concentração plasmática de biomarcadores inflamatórios em estudo de base populacional
• Beneficiário: Marcelo Macedo Rogero
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/01740-8 - Associação entre polimorfismos de nucleotídeo único relacionados aos genes da adiponectina, receptor do tipo Toll 4, IL-1² e IL-6 e ingestão de lipídios e seus efeitos sobre um padrão inflamatório sistêmico em um estudo de base populacional- ISA-Capital
• Beneficiário: Marina Maintinguer Norde
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 13/01741-4 - Associação entre polimorfismos de nucleotídeo único relacionados aos genes da proteína C reativa, TNF-alfa e IL-10 e ácidos graxos plasmáticos e seus efeitos sobre um padrão inflamatório sistêmico em estudo de base populacional - ISA-Capital
• Beneficiário: Érica Oki
• Modalidade de apoio: Bolsas no Brasil - Mestrado