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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between 25-hydroxyvitamin D and inflammatory biomarker levels in a cross-sectional population-based study, Sao Paulo, Brazil

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Author(s):
de Souza, Wysllenny N. [1] ; Norde, Marina M. [1] ; Oki, Erica [1] ; Rogero, Marcelo M. [1] ; Marchioni, Dirce M. L. [1] ; Fisberg, Regina M. [1] ; Martini, Ligia A. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Sch Publ Hlth, Dept Nutr, Ave Dr Arnaldo 715, BR-01246904 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Nutrition Research; v. 36, n. 1, p. 1-8, JAN 2016.
Web of Science Citations: 8
Abstract

Besides the classic vitamin D function on bone homeostasis, there are bodies of evidence showing that adequate status of vitamin D can modulate inflammation. We hypothesized that higher plasma levels of 25-hydroxyvitamin D (25{[}OH]D) would correlate with lower plasma levels of proinflammatory cytokines, acute-phase proteins, and soluble adhesion molecules and higher plasma levels of anti-inflammatory cytokines. We included all adults (age, 20-59 years) of the population-based, cross-sectional study, Health Survey-Sao Paulo, conducted in Sao Paulo (Brazil) in the study (n = 281). Anthropometric parameters, blood pressure measurements, and a fasting blood sample were collected by trained fieldworkers. Serum 25(OH)D concentration, plasma inflammatory biomarker levels (C-reactive protein, interleukin {[}IL]-1 beta, IL-6, IL-8, IL-10, tumor necrosis factor {[}TNF] alpha, IL-12p70, adiponectin, monocyte chemoattractant protein-1, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1), and plasma blood lipid parameters were evaluated. The prevalence of vitamin D inadequacy (<50 nmol/L) was 65.5%. Inadequate participants were younger, with lower body mass index (BMI), systolic and diastolic blood pressures, triglyceride, and total cholesterol levels as well as low-density lipoprotein cholesterol, compared with individuals adequate for vitamin D status. After adjustment, plasma concentration of soluble intercellular adhesion molecule-1 was statistically higher among adequate participants. Stratifying for BMI categories, a negative association was observed between plasma IL-6 and TNF-alpha levels and serum 25(OH)D concentration in normal-weight participants, whereas a negative association was detected between plasma adiponectin level and serum 25(OH)D concentration in overweight participants. The present findings suggest that BMI interacts with serum 25(OH)D levels, modulating inflammatory response and affecting plasma IL-6, TNF-alpha, and adiponectin levels. These data indicate that BMI plays a determinant role in the vitamin D-inflammation axis. (C) 2016 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/20401-7 - Association between SNP related to adiponectin, C-reactive protein, Toll Like Receptor 4, TNF-alfa, IL-1 beta, IL-6 and IL-10 genes and lipids intake and their effects on plasma inflammatory biomarkers levels in population-based study
Grantee:Marcelo Macedo Rogero
Support Opportunities: Regular Research Grants
FAPESP's process: 13/01740-8 - Association between single nucleotide polymorphism related to adiponectin, Toll like receptor 4, IL-1² and IL-6 genes and fatty acids intake and their effects on systemic inflammatory pattern in a population based study - ISA capital.
Grantee:Marina Maintinguer Norde
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 13/01741-4 - Association between single nucleotide polymorphism in genes of CRP, TNF-alfa and IL-10 and plasma fatty acids and their effect to a systemic inflammatory patter at a population-based study - ISA-Capital
Grantee:Érica Oki
Support Opportunities: Scholarships in Brazil - Master