Combined treatment with caffeic and ferulic acid from Baccharis uncinella C. DC. (Asteraceae) protects against metabolic syndrome in mice

Autor(es):Mostrar menos -

Bocco, B. M. ^{[1, 2]} ; Fernandes, G. W. ^{[1, 2]} ; Lorena, F. B. ^{[1, 2]} ; Cysneiros, R. M. ^[1] ; Christoffolete, M. A. ^[3] ; Grecco, S. S. ^[3] ; Lancellotti, C. L. ^[4] ; Romoff, P. ^[5] ; Lago, J. H. G. ^[6] ; Bianco, A. C. ^[7] ; Ribeiro, M. O. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Presbiteriana Mackenzie, Programa Posgrad Disturbios Desenvolvimento, Ctr Ciencias Biol & Saude, Sao Paulo, SP - Brazil

^[2] Univ Fed Sao Paulo, Dept Med Translac, Escola Paulista Med, Sao Paulo, SP - Brazil

^[3] Univ Fed ABC, Ctr Ciencias Nat & Humanas, Sao Paulo, SP - Brazil

^[4] Escola Ciencias Med, Dept Ciencias Patol, Sao Paulo, SP - Brazil

^[5] Univ Presbiteriana Mackenzie, Escola Engn, Sao Paulo, SP - Brazil

^[6] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Sao Paulo, SP - Brazil

^[7] Rush Univ & Med Ctr, Dept Internal Med, Div Endocrinol & Metab, Chicago, IL 60612 - USA

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Medical and Biological Research; v. 49, n. 3 MAR 2016.
• Citações Web of Science: 4

Resumo

Fractionation of the EtOH extract from aerial parts of Baccharis uncinella C. DC. (Asteraceae) led to isolation of caffeic and ferulic acids, which were identified from spectroscopic and spectrometric evidence. These compounds exhibit antioxidant and anti-inflammatory properties and have been shown to be effective in the prevention/treatment of metabolic syndrome. This study investigated whether the combined treatment of caffeic and ferulic acids exhibits a more significant beneficial effect in a mouse model with metabolic syndrome. The combination treatment with caffeic and ferulic acids was tested for 60 days in C57 mice kept on a high-fat (40%) diet. The data obtained indicated that treatment with caffeic and ferulic acids prevented gain in body weight induced by the high-fat diet and improved hyperglycemia, hypercholesterolemia and hypertriglyceridemia. The expression of a number of metabolically relevant genes was affected in the liver of these animals, showing that caffeic and ferulic acid treatment results in increased cholesterol uptake and reduced hepatic triglyceride synthesis in the liver, which is a likely explanation for the prevention of hepatic steatosis. In conclusion, the combined treatment of caffeic and ferulic acids displayed major positive effects towards prevention of multiple aspects of the metabolic syndrome and liver steatosis in an obese mouse model. (AU)

• Processo FAPESP: 11/21847-6 - Papel do receptor adrenérgico beta1 no desenvolvimento da doença hepática não-alcoólica
• Beneficiário: Miriam Oliveira Ribeiro
• Modalidade de apoio: Auxílio à Pesquisa - Regular