Tumor Necrosis Factor-Alpha Levels After Surgical Anti-infective Mechanical Therapy for Peri-Implantitis: A 12-Month Follow-Up

Autor(es)

de Mendonca, Adriana Cutrim ^[1] ; Santos, Vanessa Renata ^[1] ; Cesar-Neto, Joao Batista ^[2] ; Duarte, Poliana Mendes ^[1]

Afiliação do(s) autor(es)

^[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Guarulhos, SP - Brazil

^[2] Univ Fed Pelotas, Sch Dent, Dept Semiol & Clin, Pelotas, RS - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Periodontology; v. 80, n. 4, p. 693-699, APR 2009.
• Citações Web of Science: 19

Resumo

Background: The aim of the present case series was to evaluate the effects of a surgical anti-infective mechanical therapy for peri-implantitis on clinical parameters and tumor necrosis factor-alpha (TNF-alpha) levels at 12 months post-therapy. Methods: Ten patients with peri-implantitis were treated with open surgical debridement, abrasive sodium carbonate air-powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these timepoints, the total amounts of TNF-alpha in the peri-implant crevicular fluid were measured by enzyme-linked immunosorbent assay. Results: At 3 and 12 months, the anti-infective therapy resulted in significant improvements in all clinical parameters (P<0.05). Moreover, the total amount of TNF-alpha was significantly reduced at 3 and 72 months after therapy compared to baseline (P<0.05), paralleling the changes in mean probing depth and bleeding on probing. Conclusion: The anti-infective mechanical therapy reduced the crevicular levels of TNF-alpha in sites affected by peri-implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters. J Periodontol 2009; 80:693-699. (AU)

• Processo FAPESP: 06/04604-4 - Expressão de RANKL e osteoprotegerina no fluido e tecido gengival em diferentes severidades da perimplantite antes e após terapia anti-infecciosa: estudo em humanos
• Beneficiário: Vanessa Renata Santos da Silva
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 05/02561-3 - Perfis microbiológico e de expressão de citocinas pró- e anti-inflamatórias associados às diferentes severidades da perimplantite: estudo em humanos
• Beneficiário: Poliana Mendes Duarte
• Modalidade de apoio: Auxílio à Pesquisa - Regular