Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tumor Necrosis Factor-Alpha Levels After Surgical Anti-infective Mechanical Therapy for Peri-Implantitis: A 12-Month Follow-Up

Full text
Author(s):
de Mendonca, Adriana Cutrim [1] ; Santos, Vanessa Renata [1] ; Cesar-Neto, Joao Batista [2] ; Duarte, Poliana Mendes [1]
Total Authors: 4
Affiliation:
[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Guarulhos, SP - Brazil
[2] Univ Fed Pelotas, Sch Dent, Dept Semiol & Clin, Pelotas, RS - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Periodontology; v. 80, n. 4, p. 693-699, APR 2009.
Web of Science Citations: 19
Abstract

Background: The aim of the present case series was to evaluate the effects of a surgical anti-infective mechanical therapy for peri-implantitis on clinical parameters and tumor necrosis factor-alpha (TNF-alpha) levels at 12 months post-therapy. Methods: Ten patients with peri-implantitis were treated with open surgical debridement, abrasive sodium carbonate air-powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these timepoints, the total amounts of TNF-alpha in the peri-implant crevicular fluid were measured by enzyme-linked immunosorbent assay. Results: At 3 and 12 months, the anti-infective therapy resulted in significant improvements in all clinical parameters (P<0.05). Moreover, the total amount of TNF-alpha was significantly reduced at 3 and 72 months after therapy compared to baseline (P<0.05), paralleling the changes in mean probing depth and bleeding on probing. Conclusion: The anti-infective mechanical therapy reduced the crevicular levels of TNF-alpha in sites affected by peri-implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters. J Periodontol 2009; 80:693-699. (AU)

FAPESP's process: 05/02561-3 - Microbiological and pro-inflammatory and anti-inflammatory cytokine expression profiles in different forms of human peri-implantitis
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants
FAPESP's process: 06/04604-4 - RANKL and osteoprotegerin expression in gingival fluid and tissue in different peri-implantitis severity before and after anti-infection therapy: a study in human beings
Grantee:Vanessa Renata Santos da Silva
Support type: Scholarships in Brazil - Master