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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tumor Necrosis Factor-Alpha Levels After Surgical Anti-infective Mechanical Therapy for Peri-Implantitis: A 12-Month Follow-Up

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de Mendonca, Adriana Cutrim [1] ; Santos, Vanessa Renata [1] ; Cesar-Neto, Joao Batista [2] ; Duarte, Poliana Mendes [1]
Total Authors: 4
[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Guarulhos, SP - Brazil
[2] Univ Fed Pelotas, Sch Dent, Dept Semiol & Clin, Pelotas, RS - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Periodontology; v. 80, n. 4, p. 693-699, APR 2009.
Web of Science Citations: 19

Background: The aim of the present case series was to evaluate the effects of a surgical anti-infective mechanical therapy for peri-implantitis on clinical parameters and tumor necrosis factor-alpha (TNF-alpha) levels at 12 months post-therapy. Methods: Ten patients with peri-implantitis were treated with open surgical debridement, abrasive sodium carbonate air-powder, and resin curets. Clinical parameters were recorded before and 3 and 12 months after therapy. At these timepoints, the total amounts of TNF-alpha in the peri-implant crevicular fluid were measured by enzyme-linked immunosorbent assay. Results: At 3 and 12 months, the anti-infective therapy resulted in significant improvements in all clinical parameters (P<0.05). Moreover, the total amount of TNF-alpha was significantly reduced at 3 and 72 months after therapy compared to baseline (P<0.05), paralleling the changes in mean probing depth and bleeding on probing. Conclusion: The anti-infective mechanical therapy reduced the crevicular levels of TNF-alpha in sites affected by peri-implantitis over a period of 12 months, and this phenomenon was associated with improvements in clinical parameters. J Periodontol 2009; 80:693-699. (AU)

FAPESP's process: 05/02561-3 - Microbiological and pro-inflammatory and anti-inflammatory cytokine expression profiles in different forms of human peri-implantitis
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants
FAPESP's process: 06/04604-4 - RANKL and osteoprotegerin expression in gingival fluid and tissue in different peri-implantitis severity before and after anti-infection therapy: a study in human beings
Grantee:Vanessa Renata Santos da Silva
Support type: Scholarships in Brazil - Master