| Texto completo | |
| Autor(es): |
Tellez, Luis A.
[1, 2]
;
Han, Wenfei
[1, 2]
;
Zhang, Xiaobing
[3]
;
Ferreira, Tatiana L.
[1, 4, 2]
;
Perez, Isaac O.
[2]
;
Shammah-Lagnado, Sara J.
[5]
;
van den Pol, Anthony N.
[3]
;
de Araujo, Ivan E.
[1, 2, 6]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT - USA
[2] John B Pierce Lab, New Haven, CT - USA
[3] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT - USA
[4] Fed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, SP - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Carlos, SP - Brazil
[6] Yale Univ, Sch Arts & Sci, Dept Physiol, New Haven, CT - USA
Número total de Afiliações: 6
|
| Tipo de documento: | Artigo Científico |
| Fonte: | NATURE NEUROSCIENCE; v. 19, n. 3, p. 465+, MAR 2016. |
| Citações Web of Science: | 68 |
| Resumo | |
Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of sugar. During sugar intake, suppressing hedonic value inhibited dopamine release in ventral, but not dorsal, striatum, whereas suppressing nutritional value inhibited dopamine release in dorsal, but not ventral, striatum. Consistently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar's ability to drive the ingestion of unpalatable solutions. Conversely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum substituted for sugar in its ability to drive the ingestion of unpalatable solutions. Our data indicate that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize energy-seeking over taste quality. (AU) | |
| Processo FAPESP: | 13/09405-3 - Caracterização dos microcircuitos neurais reguladores das compulsões por carboidratos |
| Beneficiário: | Tatiana Lima Ferreira |
| Modalidade de apoio: | Bolsas no Exterior - Pesquisa |