| Full text | |
| Author(s): |
Tellez, Luis A.
[1, 2]
;
Han, Wenfei
[1, 2]
;
Zhang, Xiaobing
[3]
;
Ferreira, Tatiana L.
[1, 4, 2]
;
Perez, Isaac O.
[2]
;
Shammah-Lagnado, Sara J.
[5]
;
van den Pol, Anthony N.
[3]
;
de Araujo, Ivan E.
[1, 2, 6]
Total Authors: 8
|
| Affiliation: | [1] Yale Univ, Sch Med, Dept Psychiat, New Haven, CT - USA
[2] John B Pierce Lab, New Haven, CT - USA
[3] Yale Univ, Sch Med, Dept Neurosurg, New Haven, CT - USA
[4] Fed Univ ABC, Math Comp & Cognit Ctr, Santo Andre, SP - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Carlos, SP - Brazil
[6] Yale Univ, Sch Arts & Sci, Dept Physiol, New Haven, CT - USA
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | NATURE NEUROSCIENCE; v. 19, n. 3, p. 465+, MAR 2016. |
| Web of Science Citations: | 68 |
| Abstract | |
Sugar exerts its potent reinforcing effects via both gustatory and post-ingestive pathways. It is, however, unknown whether sweetness and nutritional signals engage segregated brain networks to motivate ingestion. We found in mice that separate basal ganglia circuitries mediated the hedonic and nutritional actions of sugar. During sugar intake, suppressing hedonic value inhibited dopamine release in ventral, but not dorsal, striatum, whereas suppressing nutritional value inhibited dopamine release in dorsal, but not ventral, striatum. Consistently, cell-specific ablation of dopamine-excitable cells in dorsal, but not ventral, striatum inhibited sugar's ability to drive the ingestion of unpalatable solutions. Conversely, optogenetic stimulation of dopamine-excitable cells in dorsal, but not ventral, striatum substituted for sugar in its ability to drive the ingestion of unpalatable solutions. Our data indicate that sugar recruits a distributed dopamine-excitable striatal circuitry that acts to prioritize energy-seeking over taste quality. (AU) | |
| FAPESP's process: | 13/09405-3 - Characterization of neural microcircuitry responsible for carbohydrates compulsions |
| Grantee: | Tatiana Lima Ferreira |
| Support Opportunities: | Scholarships abroad - Research |