A pharmacological perspective on the use of Brazilian Red Propolis and its isolated compounds against human diseases

Autor(es)

Freires, Irlan Almeida ^[1] ; de Alencar, Severino Matias ^[2] ; Rosalen, Pedro Luiz ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Physiol Sci, 901 Limeira Ave, Piracicaba, SP - Brazil

^[2] Univ Sao Paulo, Dept Agri Food Ind Food & Nutr, Luiz de Queiroz Coll Agr, Piracicaba, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY; v. 110, p. 267-279, MAR 3 2016.
• Citações Web of Science: 35

Resumo

Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and economic value. The nutraceutical and pharmacological benefits of propolis have been extensively explored in several fields of medicine as an important resource for prevention and treatment of oral and systemic diseases. A relatively new type of propolis, named red propolis (in Brazil, Brazilian Red Propolis - BRP), has been arousing attention for the promising pharmacological properties of some of its isolated compounds (vestitol, neovestitol, quercetin, medicarpin, formononetin, etc). Due to a distinct chemical composition, BRP and its isolated compounds (mainly isoflavones) affect a wide range of biological targets and could have an impact against numerous diseases as an antimicrobial, anti-inflammatory and immunomodulatory, antioxidant and antiproliferative agent. In this review, we comprehensively address the main aspects related to BRP bioprospection, chemistry and therapeutic potential. Further information is provided on mechanisms of action discovered thus far as well as clinical use in humans and regulatory aspects. As of now, BRP and its isolated molecules remain a fascinating topic for further research and application in biomedical areas and dentistry. (C) 2016 Elsevier Masson SAS. All rights reserved. (AU)

• Processo FAPESP: 11/15984-0 - Avaliação da atividade anti-Candida, antiproliferativa e citotóxica do óleo essencial e frações de Coriandrum sativum L.
• Beneficiário: Irlan de Almeida Freires
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/58492-8 - Avaliação das atividades antibacteriana, anticárie e anti-inflamatória do(s) novo(s) composto(s) da própolis vermelha
• Beneficiário: Severino Matias de Alencar
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 13/25080-7 - Prevalência de cepas de Streptococcus mutans expressando Cnm de crianças e adultos e o papel desta glicoproteína nas interações patógeno-hospedeiro
• Beneficiário: Irlan de Almeida Freires
• Modalidade de apoio: Bolsas no Brasil - Doutorado