The GATA3 gene is involved in leprosy susceptibility in Brazilian patients

Autor(es)

Medeiros, Priscila ^[1] ; da Silva, Weber Laurentino ^[1] ; de Oliveira Gimenez, Bruna Beatriz ^[1] ; Vallezi, Keren Bastos ^[1] ; Moraes, Milton Ozorio ^[2] ; Brito de Souza, Vania Nieto ^[1] ; Pereira Latini, Ana Carla ^[1]

Afiliação do(s) autor(es)

^[1] Inst Lauro Souza Lima, Rodovia Comandante Joao Ribeiro Barros Km 225-226, BR-1703497 Bauru, SP - Brazil

^[2] Fiocruz MS, Inst Oswaldo Cruz, Lab Hanseniase, Ave Brasil 4365, Rio De Janeiro - Brazil

• Tipo de documento: Artigo Científico
• Fonte: INFECTION GENETICS AND EVOLUTION; v. 39, p. 194-200, APR 2016.
• Citações Web of Science: 1

Resumo

Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 09/16873-8 - Epidemiologia genética em hanseníase: estudo de associação das regiões genômicas candidatas 6p21, 17q22, 20p13 e 10p13
• Beneficiário: Ana Carla Pereira Latini
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 14/04143-3 - Avaliação dos efeitos funcionais do polimorfismo rs10905284 no gene GATA3 na resposta imune frente ao Mycobacterium leprae
• Beneficiário: Bruna Beatriz de Oliveira Gimenez
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica