The GATA3 gene is involved in leprosy susceptibility in Brazilian patients

Author(s)

Medeiros, Priscila ^[1] ; da Silva, Weber Laurentino ^[1] ; de Oliveira Gimenez, Bruna Beatriz ^[1] ; Vallezi, Keren Bastos ^[1] ; Moraes, Milton Ozorio ^[2] ; Brito de Souza, Vania Nieto ^[1] ; Pereira Latini, Ana Carla ^[1]

Affiliation

^[1] Inst Lauro Souza Lima, Rodovia Comandante Joao Ribeiro Barros Km 225-226, BR-1703497 Bauru, SP - Brazil

^[2] Fiocruz MS, Inst Oswaldo Cruz, Lab Hanseniase, Ave Brasil 4365, Rio De Janeiro - Brazil

• Document type: Journal article
• Source: INFECTION GENETICS AND EVOLUTION; v. 39, p. 194-200, APR 2016.
• Web of Science Citations: 1

Abstract

Leprosy outcome is a complex trait and the host-pathogen-environment interaction defines the emergence of the disease. Host genetic risk factors have been successfully associated to leprosy. The 10p13 chromosomal region was linked to leprosy in familial studies and GATA3 gene is a strong candidate to be part of this association. Here, we tested tag single nucleotide polymorphisms at GATA3 in two case-control samples from Brazil comprising a total of 1633 individuals using stepwise strategy. The A allele of rs10905284 marker was associated with leprosy resistance. Then, a functional analysis was conducted and showed that individuals carrying AA genotype express higher levels of GATA-3 protein in lymphocytes. So, we confirmed that the rs10905284 is a locus associated to leprosy and influences the levels of this transcription factor in the Brazilian population. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• FAPESP's process: 09/16873-8 - Genetic epidemiology in leprosy: association study of 6p21, 17q22, 20p13 and 10p13 candidate regions
• Grantee: Ana Carla Pereira Latini
• Support Opportunities: Regular Research Grants
• FAPESP's process: 14/04143-3 - Evaluation of functional effects of rs10905284 polymorphism in GATA3 gene in the immune response against Mycobacterium leprae
• Grantee: Bruna Beatriz de Oliveira Gimenez
• Support Opportunities: Scholarships in Brazil - Scientific Initiation