The Adverse Effects of Smoking on Health Outcomes in Bipolar Disorder: A Review and Synthesis of Biological Mechanisms

Autor(es)

Slyepchenko, A. ^[1] ; Brunoni, A. R. ^{[2, 3]} ; McIntyre, R. S. ^{[4, 5, 6]} ; Quevedo, J. ^{[7, 8]} ; Carvalho, A. F. ^{[9, 10]}

Afiliação do(s) autor(es)

^[1] McMaster Univ, McMaster Integrat Neurosci Discovery & Study, Hamilton, ON - Canada

^[2] Univ Sao Paulo, Univ Hosp, Interdisciplinary Ctr Appl Neuromodulat CINA, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM27, SIN, Sao Paulo - Brazil

^[4] Univ Toronto, Dept Psychiat, Toronto, ON - Canada

^[5] Univ Toronto, Dept Pharmacol, Toronto, ON - Canada

^[6] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON - Canada

^[7] Univ Texas Houston, Med Sch Houston, Dept Psychiat & Behav Sci, Ctr Expt Models Psychiat, Houston, TX - USA

^[8] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Neurosci Lab, Criciuma, SC - Brazil

^[9] Univ Fed Ceara, Fac Med, Dept Clin Med, Rua Prof Costa Mendes, 1608, 4o Andar, BR-60430040 Fortaleza, CE - Brazil

^[10] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, BR-60430040 Fortaleza, CE - Brazil

• Tipo de documento: Artigo Científico
• Fonte: CURRENT MOLECULAR MEDICINE; v. 16, n. 2, p. 187-205, 2016.
• Citações Web of Science: 4

Resumo

Several biological systems are implicated in the neuroprogression of bipolar disorder including but not limited to cytokine levels, oxidative stress markers, monoamine levels, tryptophan catabolite and glutamate-mediated excitotoxicity, microglial activation as well as structural and functional changes. The high rate of smoking behaviour in individuals with bipolar disorder provides the impetus for exploring shared and discrete pathogenetic mechanisms. In addition to contributing to increased mortality, smoking activates several neurobiological effector systems implicated in the progression of bipolar disorder. Here, a narrative review provides evidence and putative mechanisms of comorbid effects of BD, cigarette use, and nicotine dependence, and discusses the clinical implications of these interactions. (AU)

• Processo FAPESP: 12/20911-5 - Escitalopram e estimulação transcraniana por corrente contínua no transtorno depressivo maior: um ensaio clínico randomizado, duplo-cego, placebo-controlado de não-inferioridade
• Beneficiário: Andre Russowsky Brunoni
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores