Advanced search
Start date
Betweenand
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The Adverse Effects of Smoking on Health Outcomes in Bipolar Disorder: A Review and Synthesis of Biological Mechanisms

Full text
Author(s):
Slyepchenko, A. [1] ; Brunoni, A. R. [2, 3] ; McIntyre, R. S. [4, 5, 6] ; Quevedo, J. [7, 8] ; Carvalho, A. F. [9, 10]
Total Authors: 5
Affiliation:
[1] McMaster Univ, McMaster Integrat Neurosci Discovery & Study, Hamilton, ON - Canada
[2] Univ Sao Paulo, Univ Hosp, Interdisciplinary Ctr Appl Neuromodulat CINA, Sao Paulo - Brazil
[3] Univ Sao Paulo, Dept & Inst Psychiat, Lab Neurosci LIM27, SIN, Sao Paulo - Brazil
[4] Univ Toronto, Dept Psychiat, Toronto, ON - Canada
[5] Univ Toronto, Dept Pharmacol, Toronto, ON - Canada
[6] Univ Toronto, Mood Disorders Psychopharmacol Unit, Toronto, ON - Canada
[7] Univ Texas Houston, Med Sch Houston, Dept Psychiat & Behav Sci, Ctr Expt Models Psychiat, Houston, TX - USA
[8] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Neurosci Lab, Criciuma, SC - Brazil
[9] Univ Fed Ceara, Fac Med, Dept Clin Med, Rua Prof Costa Mendes, 1608, 4o Andar, BR-60430040 Fortaleza, CE - Brazil
[10] Univ Fed Ceara, Fac Med, Translat Psychiat Res Grp, BR-60430040 Fortaleza, CE - Brazil
Total Affiliations: 10
Document type: Journal article
Source: CURRENT MOLECULAR MEDICINE; v. 16, n. 2, p. 187-205, 2016.
Web of Science Citations: 4
Abstract

Several biological systems are implicated in the neuroprogression of bipolar disorder including but not limited to cytokine levels, oxidative stress markers, monoamine levels, tryptophan catabolite and glutamate-mediated excitotoxicity, microglial activation as well as structural and functional changes. The high rate of smoking behaviour in individuals with bipolar disorder provides the impetus for exploring shared and discrete pathogenetic mechanisms. In addition to contributing to increased mortality, smoking activates several neurobiological effector systems implicated in the progression of bipolar disorder. Here, a narrative review provides evidence and putative mechanisms of comorbid effects of BD, cigarette use, and nicotine dependence, and discusses the clinical implications of these interactions. (AU)

FAPESP's process: 12/20911-5 - Escitalopram and transcranial direct current stimulation in major depressive disorder: a double blind, placebo-controlled, randomized, non-inferiority trial
Grantee:Andre Russowsky Brunoni
Support Opportunities: Research Grants - Young Investigators Grants