| Texto completo | |
| Autor(es): |
Carrasco-Garcia, Estefania
[1]
;
Santos, Juliana C.
[2]
;
Garcia, Idoia
[1, 3]
;
Brianti, Mitsue
[2]
;
Garcia-Puga, Mikel
[1]
;
Jr Pedrazzoli, Jose
;
Matheu, Ander
[1, 3]
;
Ribeiro, Marcelo L.
[4]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] Biodonostia Hlth Res Inst, Neurooncol Grp, Paseo Dr Beguiristain S-N, San Sebastian 20014 - Spain
[2] Univ San Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP - Brazil
[3] Ikerbasque, Basque Fdn, E-48011 Bilbao - Spain
[4] Jr Pedrazzoli, Jr., Jose, Univ San Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo de Revisão |
| Fonte: | AMERICAN JOURNAL OF CANCER RESEARCH; v. 6, n. 4, p. 701-713, 2016. |
| Citações Web of Science: | 16 |
| Resumo | |
Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology. (AU) | |
| Processo FAPESP: | 14/11862-6 - Avaliação do papel regulatório de genes associados à via Wnt/b-catenina sob os mecanismos de reparo ao DNA modulados por H. pylori |
| Beneficiário: | Marcelo Lima Ribeiro |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |
| Processo FAPESP: | 11/21710-0 - DETERMINAÇÃO DO PERFIL EPIGENÉTICO RELACIONADO AOS SISTEMAS DE REPARO AO DNA INFLUENCIADOS PELA INFECÇÃO POR H. pylori |
| Beneficiário: | Juliana Carvalho Santos |
| Modalidade de apoio: | Bolsas no Brasil - Doutorado |