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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Paradoxical role of SOX2 in gastric cancer

Author(s):
Carrasco-Garcia, Estefania [1] ; Santos, Juliana C. [2] ; Garcia, Idoia [1, 3] ; Brianti, Mitsue [2] ; Garcia-Puga, Mikel [1] ; Jr Pedrazzoli, Jose ; Matheu, Ander [1, 3] ; Ribeiro, Marcelo L. [4]
Total Authors: 8
Affiliation:
[1] Biodonostia Hlth Res Inst, Neurooncol Grp, Paseo Dr Beguiristain S-N, San Sebastian 20014 - Spain
[2] Univ San Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP - Brazil
[3] Ikerbasque, Basque Fdn, E-48011 Bilbao - Spain
[4] Jr Pedrazzoli, Jr., Jose, Univ San Francisco, Unidade Integrada Farmacol & Gastroenterol, Braganca Paulista, SP - Brazil
Total Affiliations: 4
Document type: Review article
Source: AMERICAN JOURNAL OF CANCER RESEARCH; v. 6, n. 4, p. 701-713, 2016.
Web of Science Citations: 16
Abstract

Sox2 is a critical regulator of embryogenesis and necessary for cellular reprogramming. It also plays an important role in tissue homeostasis and regeneration, maintaining the population of undifferentiated adult stem cells. Like various developmental and stem cell genes, SOX2 is aberrantly expressed and amplified in several human cancers. Moreover, functional studies have shown that it regulates many biological processes including cell proliferation, apoptosis, self-renewal and invasion. While it is oncogenic in most cancers, SOX2 activity is controversial in gastric cancer, where it might behave as a tumor suppressor in some situations. In this review, we discuss its role in cancer biology, with particular attention to what is known about the involvement of SOX2 in gastric cancer biology. (AU)

FAPESP's process: 14/11862-6 - Evaluation of the regulatory role of genes associated with the via Wnt/b-catenin on the mechanisms of the DNA repair modulated by H. pylori
Grantee:Marcelo Lima Ribeiro
Support type: Regular Research Grants
FAPESP's process: 11/21710-0 - Analysis of epigenetic profile related with DNA repair systems influenced by H. pylori infection
Grantee:Juliana Carvalho Santos
Support type: Scholarships in Brazil - Doctorate