| Texto completo | |
| Autor(es): |
Colombo, Natalia Helena
[1]
;
Pereira, Jesse Augusto
[1]
;
Rodrigues da Silva, Marjully Eduardo
[1]
;
Fonseca Ribas, Lais Fernanda
[1]
;
Parisotto, Thais Manzano
[2]
;
Mattos-Graner, Renata de Oliveira
[3]
;
Smith, Daniel J.
[4]
;
Duque, Cristiane
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] UNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, R Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Sao Francisco, Sch Dent, Lab Microbiol & Mol Biol, BR-12900000 Braganca Paulista, SP - Brazil
[3] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil
[4] Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA - USA
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | ARCHIVES OF ORAL BIOLOGY; v. 67, p. 22-27, JUL 2016. |
| Citações Web of Science: | 5 |
| Resumo | |
Objective: Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved. (AU) | |
| Processo FAPESP: | 13/12167-7 - Influência de fatores ambientais, dos níveis de microrganismos potencialmente cariogênicos e de peptídeos antimicrobianos no desenvolvimento da cárie precoce da infância |
| Beneficiário: | Lais Fernanda Fonseca Ribas |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 12/19235-5 - Papel antimicrobiano e imunológico de peptídeos catiônicos na prevenção da cárie precoce da infância e uma proposta de incorporação de fragmentos desses peptídeos em sistemas de nanopartículas como agentes anticárie |
| Beneficiário: | Cristiane Duque |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |