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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship between the IgA antibody response against Streptococcus mutans GbpB and severity of dental caries in childhood

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Author(s):
Colombo, Natalia Helena [1] ; Pereira, Jesse Augusto [1] ; Rodrigues da Silva, Marjully Eduardo [1] ; Fonseca Ribas, Lais Fernanda [1] ; Parisotto, Thais Manzano [2] ; Mattos-Graner, Renata de Oliveira [3] ; Smith, Daniel J. [4] ; Duque, Cristiane [1]
Total Authors: 8
Affiliation:
[1] UNESP Univ Estadual Paulista, Aracatuba Dent Sch, Dept Pediat Dent & Publ Hlth, R Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[2] Univ Sao Francisco, Sch Dent, Lab Microbiol & Mol Biol, BR-12900000 Braganca Paulista, SP - Brazil
[3] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba, SP - Brazil
[4] Forsyth Inst, Dept Immunol & Infect Dis, Cambridge, MA - USA
Total Affiliations: 4
Document type: Journal article
Source: ARCHIVES OF ORAL BIOLOGY; v. 67, p. 22-27, JUL 2016.
Web of Science Citations: 5
Abstract

Objective: Explore the associations between the severity of dental caries in childhood, mutans streptococci (MS) levels and IgA antibody response against Streptococcus mutans GbpB. Moreover, other caries-related etiological factors were also investigated. Design: 36-60 month-old children were grouped into Caries-Free (CF, n = 19), Early Childhood Caries (ECC, n = 17) and Severe Early Childhood Caries (S-ECC, n = 21). Data from socio-economic-cultural status, oral hygiene habits and dietary patterns were obtained from a questionnaire and a food-frequency diary filled out by parents. Saliva was collected from children for microbiological analysis and detection of salivary IgA antibody reactive with S. mutans GbpB in western blot. Results: S-ECC children had reduced family income compared to those with ECC and CF. There was difference between CF and caries groups (ECC and S-ECC) in MS counts. Positive correlations between salivary IgA antibody response against GbpB and MS counts were found when the entire population was evaluated. When children with high MS counts were compared, S-ECC group showed significantly lower IgA antibody levels to GbpB compared to CF group. This finding was not observed for the ECC group. Conclusions: This study suggests that children with S-ECC have reduced salivary IgA immune responses to S. mutans GbpB, potentially compromising their ability to modify MS infection and its cariogenic potential. Furthermore, a reduced family income and high levels of MS were also associated with S-ECC. (C) 2016 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/12167-7 - Influence of environmental factors, levels of potentially cariogenic microorganisms and antimicrobial peptides on the development of early childhood caries
Grantee:Lais Fernanda Fonseca Ribas
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/19235-5 - Antimicrobial and immunological role of cationic peptides in the prevention of early childhood caries and a proposal for incorporation of these peptides in nanoparticles systems as anticaries agents
Grantee:Cristiane Duque
Support Opportunities: Regular Research Grants