Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study

Autor(es)

Kemp, Andrew H. ^{[1, 2, 3, 4]} ; Rodriguez Lopez, Santiago ^{[1, 2, 5]} ; Passos, Valeria M. A. ^[6] ; Bittencourt, Marcio S. ^{[1, 2]} ; Dantas, Eduardo M. ^[7] ; Mill, Jose G. ^[8] ; Ribeiro, Antonio L. P. ^{[9, 6]} ; Thayer, Julian F. ^[10] ; Bensenor, Isabela M. ^{[1, 2]} ; Lotufo, Paulo A. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Univ Hosp, Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil

^[3] Univ Sydney, Sch Psychol, Sydney, NSW 2006 - Australia

^[4] Univ Sydney, Discipline Psychiat, Sydney, NSW 2006 - Australia

^[5] Univ Autonoma Madrid, Dept Biol, E-28049 Madrid - Spain

^[6] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG - Brazil

^[7] Fed Univ Vale do Sao Francisco, Collegiate Biol Sci, Petrolina, PE - Brazil

^[8] Fed Univ Espitrito Santo, Dept Physiol Sci, Vitoiria - Brazil

^[9] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG - Brazil

^[10] Ohio State Univ, Dept Psychol, 1835 Neil Ave, Columbus, OH 43210 - USA

• Tipo de documento: Artigo Científico
• Fonte: BIOLOGICAL PSYCHOLOGY; v. 117, p. 216-224, MAY 2016.
• Citações Web of Science: 13

Resumo

Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a `spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment. (C) 2016 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 13/50327-6 - Predicting adverse events in patients with acute coronary syndrome: an examination of the role of depression and autonomic imbalance
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Regular