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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insulin resistance and carotid intima-media thickness mediate the association between resting-state heart rate variability and executive function: A path modelling study

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Kemp, Andrew H. [1, 2, 3, 4] ; Rodriguez Lopez, Santiago [1, 2, 5] ; Passos, Valeria M. A. [6] ; Bittencourt, Marcio S. [1, 2] ; Dantas, Eduardo M. [7] ; Mill, Jose G. [8] ; Ribeiro, Antonio L. P. [9, 6] ; Thayer, Julian F. [10] ; Bensenor, Isabela M. [1, 2] ; Lotufo, Paulo A. [1, 2]
Total Authors: 10
[1] Univ Sao Paulo, Univ Hosp, Sao Paulo - Brazil
[2] Univ Sao Paulo, Fac Med, Sao Paulo - Brazil
[3] Univ Sydney, Sch Psychol, Sydney, NSW 2006 - Australia
[4] Univ Sydney, Discipline Psychiat, Sydney, NSW 2006 - Australia
[5] Univ Autonoma Madrid, Dept Biol, E-28049 Madrid - Spain
[6] Univ Fed Minas Gerais, Fac Med, Belo Horizonte, MG - Brazil
[7] Fed Univ Vale do Sao Francisco, Collegiate Biol Sci, Petrolina, PE - Brazil
[8] Fed Univ Espitrito Santo, Dept Physiol Sci, Vitoiria - Brazil
[9] Univ Fed Minas Gerais, Hosp Clin, Belo Horizonte, MG - Brazil
[10] Ohio State Univ, Dept Psychol, 1835 Neil Ave, Columbus, OH 43210 - USA
Total Affiliations: 10
Document type: Journal article
Source: BIOLOGICAL PSYCHOLOGY; v. 117, p. 216-224, MAY 2016.
Web of Science Citations: 13

Background: Research has linked high-frequency heart rate variability (HF-HRV) to cognitive function. The present study adopts a modern path modelling approach to understand potential causal pathways that may underpin this relationship. Methods: Here we examine the association between resting-state HF-HRV and executive function in a large sample of civil servants from Brazil (N = 8114) recruited for the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). HF-HRV was calculated from 10-min resting-state electrocardiograms. Executive function was assessed using the trail-making test (version B). Results and conclusions: Insulin resistance (a marker of type 2 diabetes mellitus) and carotid intima-media thickness (subclinical atherosclerosis) mediated the relationship between HRV and executive function in seriatim. A limitation of the present study is its cross-sectional design; therefore, conclusions must be confirmed in longitudinal study. Nevertheless, findings support that possibility that HRV provides a `spark' that initiates a cascade of adverse downstream effects that subsequently leads to cognitive impairment. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/50327-6 - Predicting adverse events in patients with acute coronary syndrome: an examination of the role of depression and autonomic imbalance
Grantee:Isabela Judith Martins Bensenor
Support type: Regular Research Grants