Nanotechnology-Based Drug Delivery Systems for Photodynamic Therapy of Cancer: A Review

Autor(es)

Fioramonti Calixto, Giovana Maria ^[1] ; Bernegossi, Jessica ^[1] ; de Freitas, Laura Marise ^[2] ; Fontana, Carla Raquel ^[2] ; Chorilli, Marlus ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Farmacos & Med, Campus Araraquara, BR-14800903 Araraquara, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Fac Ciencias Farmaceut, Dept Anal Clin, Campus Araraquara, BR-14800903 Araraquara, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Molecules; v. 21, n. 3 MAR 2016.
• Citações Web of Science: 70

Resumo

Photodynamic therapy (PDT) is a promising alternative approach for improved cancer treatment. In PDT, a photosensitizer (PS) is administered that can be activated by light of a specific wavelength, which causes selective damage to the tumor and its surrounding vasculature. The success of PDT is limited by the difficulty in administering photosensitizers (PSs) with low water solubility, which compromises the clinical use of several molecules. Incorporation of PSs in nanostructured drug delivery systems, such as polymeric nanoparticles (PNPs), solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), gold nanoparticles (AuNPs), hydrogels, liposomes, liquid crystals, dendrimers, and cyclodextrin is a potential strategy to overcome this difficulty. Additionally, nanotechnology-based drug delivery systems may improve the transcytosis of a PS across epithelial and endothelial barriers and afford the simultaneous co-delivery of two or more drugs. Based on this, the application of nanotechnology in medicine may offer numerous exciting possibilities in cancer treatment and improve the efficacy of available therapeutics. Therefore, the aim of this paper is to review nanotechnology-based drug delivery systems for photodynamic therapy of cancer. (AU)

• Processo FAPESP: 13/01565-1 - Sistemas precursores de cristais líquidos mucoadesivos para administração bucal de peptídeo antigelatinolítico associados à terapia fotodinâmica no tratamento do câncer bucal
• Beneficiário: Giovana Maria Fioramonti Calixto Balian
• Modalidade de apoio: Bolsas no Brasil - Doutorado
• Processo FAPESP: 14/24581-5 - Avaliação do papel da terapia fotodinâmica combinada a peptídeos antimicrobianos frente à resistência bacteriana
• Beneficiário: Laura Marise de Freitas
• Modalidade de apoio: Bolsas no Brasil - Doutorado