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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Translational control by eIF2 alpha in neurons: Beyond the stress response

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Autor(es):
Bellato, Hermano Martins ; Maroso Hajj, Glaucia Noeli
Número total de Autores: 2
Tipo de documento: Artigo de Revisão
Fonte: CYTOSKELETON; v. 73, n. 10, p. 551-565, OCT 2016.
Citações Web of Science: 11
Resumo

The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2) is one of the mechanisms of translational control. The phosphorylation of eIF2 has classically been viewed as a stress response, halting translation initiation. However, in the nervous system this type of regulation has been related to other mechanisms besides stress response, such as behavior, memory consolidation and nervous system development. Additionally, neurodegenerative diseases have a major stress component, thus eIF2 phosphorylation plays a preeminent role and its modulation is currently viewed as a new opportunity for therapeutic interventions. This review consolidates current information regarding eIF2 phosphorylation in neurons and its impact in neurodegenerative diseases. (c) 2016 Wiley Periodicals, Inc. (AU)

Processo FAPESP: 14/04513-5 - Identificação de alterações moleculares em tumores de mama: uma abordagem traducional
Beneficiário:Hermano Martins Bellato
Linha de fomento: Bolsas no Brasil - Doutorado Direto
Processo FAPESP: 14/15550-9 - Controle traducional no câncer
Beneficiário:Glaucia Noeli Maroso Hajj
Linha de fomento: Auxílio à Pesquisa - Regular