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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Translational control by eIF2 alpha in neurons: Beyond the stress response

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Author(s):
Bellato, Hermano Martins ; Maroso Hajj, Glaucia Noeli
Total Authors: 2
Document type: Review article
Source: CYTOSKELETON; v. 73, n. 10, p. 551-565, OCT 2016.
Web of Science Citations: 11
Abstract

The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2) is one of the mechanisms of translational control. The phosphorylation of eIF2 has classically been viewed as a stress response, halting translation initiation. However, in the nervous system this type of regulation has been related to other mechanisms besides stress response, such as behavior, memory consolidation and nervous system development. Additionally, neurodegenerative diseases have a major stress component, thus eIF2 phosphorylation plays a preeminent role and its modulation is currently viewed as a new opportunity for therapeutic interventions. This review consolidates current information regarding eIF2 phosphorylation in neurons and its impact in neurodegenerative diseases. (c) 2016 Wiley Periodicals, Inc. (AU)

FAPESP's process: 14/15550-9 - Translational control in cancer
Grantee:Glaucia Noeli Maroso Hajj
Support type: Regular Research Grants
FAPESP's process: 14/04513-5 - Identification of molecular alterations in breast tumors: a translational approach
Grantee:Hermano Martins Bellato
Support type: Scholarships in Brazil - Doctorate (Direct)