| Full text | |
| Author(s): |
Bellato, Hermano Martins
;
Maroso Hajj, Glaucia Noeli
Total Authors: 2
|
| Document type: | Review article |
| Source: | CYTOSKELETON; v. 73, n. 10, p. 551-565, OCT 2016. |
| Web of Science Citations: | 11 |
| Abstract | |
The translation of mRNAs is a tightly controlled process that responds to multiple signaling pathways. In neurons, this control is also exerted locally due to the differential necessity of proteins in axons and dendrites. The phosphorylation of the alpha subunit of the translation initiation factor 2 (eIF2) is one of the mechanisms of translational control. The phosphorylation of eIF2 has classically been viewed as a stress response, halting translation initiation. However, in the nervous system this type of regulation has been related to other mechanisms besides stress response, such as behavior, memory consolidation and nervous system development. Additionally, neurodegenerative diseases have a major stress component, thus eIF2 phosphorylation plays a preeminent role and its modulation is currently viewed as a new opportunity for therapeutic interventions. This review consolidates current information regarding eIF2 phosphorylation in neurons and its impact in neurodegenerative diseases. (c) 2016 Wiley Periodicals, Inc. (AU) | |
| FAPESP's process: | 14/15550-9 - Translational control in cancer |
| Grantee: | Glaucia Noeli Maroso Hajj |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 14/04513-5 - Identification of molecular alterations in breast tumors: a translational approach |
| Grantee: | Hermano Martins Bellato |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |