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Translational control in cancer

Abstract

Cellular processes such as proliferation and differentiation are dependent on the correct control of mRNA translation. It is well known that the translation of mRNAs that promote tumor growth is favored by alterations in signaling pathways that regulate the process of protein synthesis. Thus, translational control in tumors is especially important for regulating gene expression at the level of protein synthesis, the effective molecular mediators of tumorigenesis. In this project, we intend to study various aspects of translational control and establish how this control affects tumor processes. For this, we intend to determine differentially translated mRNAs in human tumors, which may lead to the identification of gene expression profiles that better reflect the population of proteins. We also intend to explore signaling pathways involved in translational control, such as PI3K/Akt, ERK1/2 and mTOR pathways in functional models and human samples. These two complementary approaches have the potential to unravel poorly understood mechanisms in tumor biology and development of new therapies. (AU)

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VEICULO: TITULO (DATA)

Scientific publications (5)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MACHADO, LUIS EDUARDO; ALVARENGA, ARTHUR WILLIAM; DA SILVA, FERNANDA FERREIRA; ROFFE, MARTIN; BEGNAMI, MARIA DIRLEI; BLEGGI TORRES, LUIS FERNANDO; DA CUNHA, ISABELA WERNECK; MARTINS, VILMA REGINA; MAROSO HAJJ, GLAUCIA NOELI. Overexpression of mTOR and p(240-244)S6 in IDH1 Wild-Type Human Glioblastomas Is Predictive of Low Survival. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v. 66, n. 6, p. 403-414, JUN 2018. Web of Science Citations: 4.
LIANG, SHUO; BELLATO, HERMANO MARTINS; LORENT, JULIE; LUPINACCI, FERNANDA C. S.; OERTLIN, CHRISTIAN; VAN HOEF, VINCENT; ANDRADE, VICTOR P.; ROFFE, MARTIN; MASVIDAL, LAIA; HAJJ, GLAUCIA N. M.; LARSSON, OLA. Polysome-profiling in small tissue samples. Nucleic Acids Research, v. 46, n. 1 JAN 9 2018. Web of Science Citations: 5.
SANTOS, TIAGO GOSS; MARTINS, VILMA REGINA; MAROSO HAJJ, GLAUCIA NOELI. Unconventional Secretion of Heat Shock Proteins in Cancer. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 18, n. 5 MAY 2017. Web of Science Citations: 18.
ALVARENGA, ARTHUR WILLIAM; MACHADO, LUIS EDUARDO; RODRIGUES, BRUNA ROZ; SULLA LUPINACCI, FERNANDA CRISTINA; SANEMASTU, PAULO; MATTA, EDUARDO; ROFFE, MARTIN; BLEGGI TORRES, LUIS FERNANDO; DA CUNHA, ISABELA WERNECK; MARTINS, VILMA REGINA; MAROSO HAJJ, GLAUCIA NOELI. Evaluation of Akt and RICTOR Expression Levels in Astrocytomas of All Grades. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, v. 65, n. 2, p. 93-103, FEB 2017. Web of Science Citations: 9.
BELLATO, HERMANO MARTINS; MAROSO HAJJ, GLAUCIA NOELI. Translational control by eIF2 alpha in neurons: Beyond the stress response. CYTOSKELETON, v. 73, n. 10, p. 551-565, OCT 2016. Web of Science Citations: 11.

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