| Grant number: | 14/15550-9 |
| Support type: | Regular Research Grants |
| Duration: | September 01, 2015 - August 31, 2018 |
| Field of knowledge: | Health Sciences - Medicine |
| Principal researcher: | Glaucia Noeli Maroso Hajj |
| Grantee: | Glaucia Noeli Maroso Hajj |
| Home Institution: | A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil |
| Assoc. researchers: | Hellen Kuasne ; Maria Dirlei Ferreira de Souza Begnami ; Martín Roffé ; Silvia Regina Rogatto ; Tiago Góss dos Santos ; Victor Piana de Andrade ; Vilma Regina Martins |
Abstract
Cellular processes such as proliferation and differentiation are dependent on the correct control of mRNA translation. It is well known that the translation of mRNAs that promote tumor growth is favored by alterations in signaling pathways that regulate the process of protein synthesis. Thus, translational control in tumors is especially important for regulating gene expression at the level of protein synthesis, the effective molecular mediators of tumorigenesis. In this project, we intend to study various aspects of translational control and establish how this control affects tumor processes. For this, we intend to determine differentially translated mRNAs in human tumors, which may lead to the identification of gene expression profiles that better reflect the population of proteins. We also intend to explore signaling pathways involved in translational control, such as PI3K/Akt, ERK1/2 and mTOR pathways in functional models and human samples. These two complementary approaches have the potential to unravel poorly understood mechanisms in tumor biology and development of new therapies. (AU)
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