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Translationa control in cancer - Part II

Grant number: 18/17796-6
Support type:Regular Research Grants
Duration: March 01, 2019 - February 28, 2021
Field of knowledge:Health Sciences - Medicine
Principal Investigator:Glaucia Noeli Maroso Hajj
Grantee:Glaucia Noeli Maroso Hajj
Home Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Assoc. researchers:Isabela Werneck da Cunha ; Martín Roffé ; Tiago Góss dos Santos ; Victor Piana de Andrade ; Vilma Regina Martins

Abstract

Cellular processes such as proliferation and differentiation depend on the correct control of mRNA translation. It is well known that the translation of mRNAs that promote tumor growth is favored by the alteration of signaling pathways that regulate the process of protein synthesis. Thus, translational control in tumors is especially important for regulating gene expression at the level of protein formation. In this project we intend to study different aspects of the translational control and how this control affects tumorigenic processes. In the first part of this project, funded by FAPESP Grant 2014/15550-9, we established an innovative method of studying differentially translated RNAs, which led to the determination of clinically relevant molecular subgroups for tumor types such as glioblastomas.In this second part of the project, we intend to validate the findings of differentially translated RNAs in glioblastomas and extend the study to other tumor types such as breast adenocarcinoma and clear cell renal carcinoma, which also have described alterations in signaling pathways that regulate translation. As a complementary strategy, proteins involved in translational control will also be evaluated in these tumors, such as translation initiation factors (eIFs). In addition, other less well-known modes of translation control will be explored, such as methylation of messenger RNAs. These pathways will be explored in functional models and human samples. These complementary approaches have the potential to unravel mechanisms still poorly understood in tumor biology and to assist both the development of new therapies and the effective application of personalized medicine to patients with selected molecular profiles. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
HAJJ, GLAUCIA N. M.; DA SILVA, FERNANDA F.; DE BELLIS, BARBARA; LUPINACCI, FERNANDA C. S.; BELLATO, HERMANO M.; CRUZ, JUVANIER R.; SEGUNDO, CLAUDIONOR N. C.; FAQUINI, V, IGOR; TORRES, LEURIDAN C.; SANEMATSU, I, PAULO; BEGNAMI, MARIA D.; MARTINS, VILMA R.; ROFFE, MARTIN. Aberrant expression of RSK1 characterizes high-grade gliomas with immune infiltration. MOLECULAR ONCOLOGY, v. 14, n. 1, p. 159-179, JAN 2020. Web of Science Citations: 0.
SULLA LUPINACCI, FERNANDA CRISTINA; KUASNE, HELLEN; ROFFE, MARTIN; VASSALAKIS, JULIA AVIAN; DA SILVA, FERNANDA FERREIRA; SANTOS, TIAGO GOSS; ANDRADE, VICTOR PIANA; SANEMATSU, PAULO; MARTINS, VILMA REGINA; ROGATTO, SILVIA REGINA; MAROSO HAJJ, GLAUCIA NOELI. Polysome Profiling of a Human Glioblastoma Reveals Intratumoral Heterogeneity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 9 MAY 1 2019. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.