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Identification of molecular alterations in breast tumors: a translational approach

Grant number: 14/04513-5
Support Opportunities:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2014
Effective date (End): August 14, 2016
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Glaucia Noeli Maroso Hajj
Grantee:Hermano Martins Bellato
Host Institution: A C Camargo Cancer Center. Fundação Antonio Prudente (FAP). São Paulo , SP, Brazil
Associated scholarship(s):15/11245-0 - Isolation of total and polysomal mRNA from breast tumor and normal samples followed by libraries construction for RNA sequencing, BE.EP.DD


Breast cancer is the most prevalent tumor type among females and has a unique complexity, with considerable heterogeneity. Breast tumors can be classified into molecular subgroups to better target the therapeutic choice. However, even among patients of the same group there is a wide range of prognostic and therapeutic behavior, demonstrating a real need to identify more precise biomarkers. The discovery of new molecular markers for this disease can both contribute to a better understanding of biological mechanisms, as well as to the development of individualized therapies. Currently, many high-throughput projects try to define general patterns of gene expression based on sequencing techniques or "microarrays" from total mRNA. However, this approach provides limited information about the molecular mediators of tumor changes, considering that the level of mRNA expression do not necessarily correspond to the levels of proteins. However, the identification of differentially translated mRNAs in tumors can lead to the discovery of gene expression profiles that better reflect the population of proteins. In this project we intend to identify preferentially translated mRNAs in human breast tumors from the A.C. Camargo Cancer Center Biobank. These results will allow us to define expression profiles that can be correlated with tumor features and also guide the discovery of proteins with altered expression that could be important mediators of tumor processes. This approach has the potential to be a powerful tool applied to the clinic, for the development of therapeutical approaches. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LIANG, SHUO; BELLATO, HERMANO MARTINS; LORENT, JULIE; LUPINACCI, FERNANDA C. S.; OERTLIN, CHRISTIAN; VAN HOEF, VINCENT; ANDRADE, VICTOR P.; ROFFE, MARTIN; MASVIDAL, LAIA; HAJJ, GLAUCIA N. M.; et al. Polysome-profiling in small tissue samples. Nucleic Acids Research, v. 46, n. 1, . (14/15550-9, 14/04513-5, 15/15451-3, 13/03315-2)
BELLATO, HERMANO MARTINS; MAROSO HAJJ, GLAUCIA NOELI. Translational control by eIF2 alpha in neurons: Beyond the stress response. CYTOSKELETON, v. 73, n. 10, p. 551-565, . (14/15550-9, 14/04513-5)

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