The Post-cenomic Era of Trichoderma reesei: What's Next?

Autor(es)

Gupta, Vijai Kumar ; Steindorff, Andrei Stecca ; de Paula, Renato Graciano ; Silva-Rocha, Rafael ; Mach-Aigner, Astrid R. ; Mach, Robert L. ; Silva, Roberto N.

• Tipo de documento: Artigo de Revisão
• Fonte: TRENDS IN BIOTECHNOLOGY; v. 34, n. 12, p. 970-982, DEC 2016.
• Citações Web of Science: 17

Resumo

The ascomycete Trichoderma reesei is one of the most well studied cellulolytic microorganisms. This fungus is widely used in the biotechnology industry, mainly in the production of biofuels. Due to its importance, its genome was sequenced in 2008, opening new avenues to study this microorganism. In this `post-genomici era, a transcriptomic and proteomic era has emerged. Here, we present an overview of new findings in the gene expression regulation network of T. reesei. We also discuss new rational strategies to obtain mutants that produce hydrolytic enzymes with a higher yield, using metabolic engineering. Finally, we present how synthetic biology strategies can be used to create engineered promoters to efficiently synthesize enzymes for biomass degradation to produce bioethanol. (AU)

• Processo FAPESP: 14/23653-2 - Caracterização de novos transportadores de açúcar envolvidos na regulação da degradação da biomassa lignocelulósica em Trichoderma reesei
• Beneficiário: Roberto do Nascimento Silva
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 12/22921-8 - Abordagens de biologia sintética para decifrar os mecanismos de integração de sinais em promotores bacterianos complexos
• Beneficiário: Rafael Silva Rocha
• Modalidade de apoio: Auxílio à Pesquisa - Jovens Pesquisadores